Juan Pablo Jiménez, MD, Ph.D., is full professor of psychiatry and a trained psychoanalyst (International Psychoanalytic Association). Currently Director of the Millennium Institute for Research on Depression and Personality (MIDAP), and former director (2000-2013) of the Department of Psychiatry and Mental Health at the University of Chile, Santiago (Eastern Campus). He was co-founder and director of the interinstitutional PhD program in psychotherapy (2007-2014) at the Universidad de Chile/Pontificia Universidad Católica de Chile, where he has led an annual seminar on the interdisciplinary study of depression for over 12 years. He is currently conducting a multi-level research project on depression and subjective well-being in college students. The multidisciplinary research team includes psychiatrists, psychologists, geneticists, public health professionals, anthropologists and mathematical engineers. He was member of the Research Committee and of the Research Advisory Board of the International Psychoanalytic Association. He was member of the faculty at the Research Training Program and visiting professor at the University College London (2007-2015). In both psychoanalysis and psychiatry, his interests revolve around the conditions for the construction of epistemological as well as methodological pluralism and interdisciplinary research in Mental Health. In this capacity he was invited to be one of the members of the committee of the International Psychoanalytical Association for the integration of theories in psychoanalysis (2008-2012).Alberto Botto, MD, Ph.D., is assistant professor of psychiatry at the Department of Psychiatry and Mental Health, University of Chile, Santiago (Eastern Campus); trained psychotherapist and researcher at the Millennium Institute for Research on Depression and Personality (MIDAP). Visiting professor Postgraduate Degree in Dynamic Psychotherapy (UPD) at the Instituto Psiquiátrico Dr. José Horwitz Barak. Visiting Professor Doctorate in Developmental Sciences and Psychopathology, Universidad del Desarrollo. Professor of Diploma in psychotherapy research for mental health professionals, Universidad Diego Portales. He is a member of the Society for Psychotherapy Research (SPR), International Association for Relational Psychoanalysis and Psychotherapy (IARPP), Sociedad Chilena para el Desarrollo de la Psiquiatría (SODEPSI), Asociación Psicoanalítica de Santiago (APSAN). He has been General Editor of the journal Gaceta de Psiquiatría Universitaria and past president of Sociedad Chilena para el Desarrollo de la Psiquiatría (SODEPSI). Author of the books: Mood Stabilizers (Ediciones Gaceta de Psiquiatría Universitaria. Temas y Controversias. Santiago, 2007) and Escorzo. Ensayos sobre psiquiatría y psicoterapia (Sodepsi Ediciones, Santiago, 2016). He is also co-author with Julia Acuña and Juan Pablo Jiménez of the book Psiquiatría para Atención Primaria y el Médico General.Depresión, ansiedad y somatización (Editorial Mediterráneo, Santiago de Chile, 2009). Currently, his research interest is focused on the epistemological and psychopathological aspects of mood disorders and specifically in the study of gene-culture interaction in depressive symptomatology and subjective well-being in Chile.Peter Fonagy, OBE, FMedSci, FBA, FAcSS, PhD, is Professor of Contemporary Psychoanalysis and Developmental Science and Director of the Division of Psychology and Language Sciences, University College London (UCL), Chief Executive, Anna Freud National Centre for Children and Families, and Programme Director, Mental Health and Wellbeing Programme, UCLPartners. His clinical interests centre on issues of mentalization theory and research, borderline psychopathology, violence and early attachment relationships. His work attempts to integrate empirical research with psychoanalytic theory. With an H-Index of 156 (Google Scholar), 85 (Scopus), – 20 publications over 1,000 citations –, he has published 609 original peer-reviewed papers and articles, 284 chapters, has authored 21 books and edited 18. He has received numerous awards for his contributions to clinical psychology and psychoanalysis, including the Order of the British Empire (OBE) and the Wiley Prize of the British Academy for Lifetime Achievements. He has had multiple professional responsibilities in the British Health Care System where he is Senior Clinical Advisor for children’s mental health and is leading task groups on numerous specific problems.

• Part I: Epistemology, Epidemiology, Psychopathology and History of Depression.- Chapter 1. The Study of Depression in the Frame of the new Research Paradigm in Psychiatry.- Chapter 2. Psychopathology of Depression in the Spectrum of Mood Disorders.- Chapter 3. Epidemiology of Depression: Burden of Disease, Trends, and the Con-tributions of Social Epidemiology to the Study of its Causes.- Chapter 4. Idioms of Depression in Contemporary Individualistic Societies: Unit-ed States and Chile.- Part II: Etiopathogenic Theories and Models.- Chapter 5. Contemporary Psychodynamic Theories on Depression.- Chapter 6. Theory and Interventions in Cognitive Behavioral Therapy for Depression.- Chapter 7. Genetic and Epigenetic Determinants of Depression: From Basic Re-search to Translational Medicine.- Chapter 8. Neurobiology of Depression.- Chapter 9. A Dimensional and Dynamic Approach to the Neurobiology of Mood Disorders: On Intermediate Phenotypes and their Interaction with Early Stress.- 10. Psychophysiology and Psychoneuroendocrinology of Stress and Re-ward in Depression.- Chapter 11. Depression and (Expert) Culture: Psychiatric, Regulatory and Moral Frameworks Underpinning the Absence of Depression in Occupation-al Health in Chile.- Chapter 12. Poverty, Social Inequity, and Depression.- Part III: Evolution and Development as an Integrating Framework.- Chapter 13. An Integrative Developmental Psychopathology Approach to Depression.- Chapter 14. Depression and Personality Dysfunction: Moving from Descriptive Comorbidity to the Identification of Common Intermediate Phenotypes.- Chapter 15. Gender and Depression: Women, Transgender and Gender Non-Conforming Depression.- Part IV: Clinical Practice as a Meeting Place for Etiopathogenic Models.- Chapter 16. Models in Depression and Clinical Judgment, or how to use Different Etiopathogenic Models with a Particular Patient.

Juan Pablo Jiménez, MD, Ph.D., is full professor of psychiatry and a trained psychoanalyst (International Psychoanalytic Association). Currently Director of the Millennium Institute for Research on Depression and Personality (MIDAP), and former director (2000-2013) of the Department of Psychiatry and Mental Health at the University of Chile, Santiago (Eastern Campus). He was co-founder and director of the interinstitutional PhD program in psychotherapy (2007-2014) at the Universidad de Chile/Pontificia Universidad Católica de Chile, where he has led an annual seminar on the interdisciplinary study of depression for over 12 years. He is currently conducting a multi-level research project on depression and subjective well-being in college students. The multidisciplinary research team includes psychiatrists, psychologists, geneticists, public health professionals, anthropologists and mathematical engineers. He was member of the Research Committee and of the Research Advisory Board of the International Psychoanalytic Association. He was member of the faculty at the Research Training Program and visiting professor at the University College London (2007-2015). In both psychoanalysis and psychiatry, his interests revolve around the conditions for the construction of epistemological as well as methodological pluralism and interdisciplinary research in Mental Health. In this capacity he was invited to be one of the members of the committee of the International Psychoanalytical Association for the integration of theories in psychoanalysis (2008-2012).Alberto Botto, MD, Ph.D., is assistant professor of psychiatry at the Department of Psychiatry and Mental Health, University of Chile, Santiago (Eastern Campus); trained psychotherapist and researcher at the Millennium Institute for Research on Depression and Personality (MIDAP). Visiting professor Postgraduate Degree in Dynamic Psychotherapy (UPD) at the Instituto Psiquiátrico Dr. José Horwitz Barak. Visiting Professor Doctorate in Developmental Sciences and Psychopathology, Universidad del Desarrollo. Professor of Diploma in psychotherapy research for mental health professionals, Universidad Diego Portales. He is a member of the Society for Psychotherapy Research (SPR), International Association for Relational Psychoanalysis and Psychotherapy (IARPP), Sociedad Chilena para el Desarrollo de la Psiquiatría (SODEPSI), Asociación Psicoanalítica de Santiago (APSAN). He has been General Editor of the journal Gaceta de Psiquiatría Universitaria and past president of Sociedad Chilena para el Desarrollo de la Psiquiatría (SODEPSI). Author of the books: Mood Stabilizers (Ediciones Gaceta de Psiquiatría Universitaria. Temas y Controversias. Santiago, 2007) and Escorzo. Ensayos sobre psiquiatría y psicoterapia (Sodepsi Ediciones, Santiago, 2016). He is also co-author with Julia Acuña and Juan Pablo Jiménez of the book Psiquiatría para Atención Primaria y el Médico General.Depresión, ansiedad y somatización (Editorial Mediterráneo, Santiago de Chile, 2009). Currently, his research interest is focused on the epistemological and psychopathological aspects of mood disorders and specifically in the study of gene-culture interaction in depressive symptomatology and subjective well-being in Chile.Peter Fonagy, OBE, FMedSci, FBA, FAcSS, PhD, is Professor of Contemporary Psychoanalysis and Developmental Science and Director of the Division of Psychology and Language Sciences, University College London (UCL), Chief Executive, Anna Freud National Centre for Children and Families, and Programme Director, Mental Health and Wellbeing Programme, UCLPartners. His clinical interests centre on issues of mentalization theory and research, borderline psychopathology, violence and early attachment relationships. His work attempts to integrate empirical research with psychoanalytic theory. With an H-Index of 156 (Google Scholar), 85 (Scopus), – 20 publications over 1,000 citations –, he has published 609 original peer-reviewed papers and articles, 284 chapters, has authored 21 books and edited 18. He has received numerous awards for his contributions to clinical psychology and psychoanalysis, including the Order of the British Empire (OBE) and the Wiley Prize of the British Academy for Lifetime Achievements. He has had multiple professional responsibilities in the British Health Care System where he is Senior Clinical Advisor for children’s mental health and is leading task groups on numerous specific problems.

• Part I: Epistemology, Epidemiology, Psychopathology and History of Depression.- Chapter 1. The Study of Depression in the Frame of the new Research Paradigm in Psychiatry.- Chapter 2. Psychopathology of Depression in the Spectrum of Mood Disorders.- Chapter 3. Epidemiology of Depression: Burden of Disease, Trends, and the Con-tributions of Social Epidemiology to the Study of its Causes.- Chapter 4. Idioms of Depression in Contemporary Individualistic Societies: Unit-ed States and Chile.- Part II: Etiopathogenic Theories and Models.- Chapter 5. Contemporary Psychodynamic Theories on Depression.- Chapter 6. Theory and Interventions in Cognitive Behavioral Therapy for Depression.- Chapter 7. Genetic and Epigenetic Determinants of Depression: From Basic Re-search to Translational Medicine.- Chapter 8. Neurobiology of Depression.- Chapter 9. A Dimensional and Dynamic Approach to the Neurobiology of Mood Disorders: On Intermediate Phenotypes and their Interaction with Early Stress.- 10. Psychophysiology and Psychoneuroendocrinology of Stress and Re-ward in Depression.- Chapter 11. Depression and (Expert) Culture: Psychiatric, Regulatory and Moral Frameworks Underpinning the Absence of Depression in Occupation-al Health in Chile.- Chapter 12. Poverty, Social Inequity, and Depression.- Part III: Evolution and Development as an Integrating Framework.- Chapter 13. An Integrative Developmental Psychopathology Approach to Depression.- Chapter 14. Depression and Personality Dysfunction: Moving from Descriptive Comorbidity to the Identification of Common Intermediate Phenotypes.- Chapter 15. Gender and Depression: Women, Transgender and Gender Non-Conforming Depression.- Part IV: Clinical Practice as a Meeting Place for Etiopathogenic Models.- Chapter 16. Models in Depression and Clinical Judgment, or how to use Different Etiopathogenic Models with a Particular Patient.

Juan Pablo Jiménez, MD, Ph.D., is full professor of psychiatry and a trained psychoanalyst (International Psychoanalytic Association). Currently Director of the Millennium Institute for Research on Depression and Personality (MIDAP), and former director (2000-2013) of the Department of Psychiatry and Mental Health at the University of Chile, Santiago (Eastern Campus). He was co-founder and director of the interinstitutional PhD program in psychotherapy (2007-2014) at the Universidad de Chile/Pontificia Universidad Católica de Chile, where he has led an annual seminar on the interdisciplinary study of depression for over 12 years. He is currently conducting a multi-level research project on depression and subjective well-being in college students. The multidisciplinary research team includes psychiatrists, psychologists, geneticists, public health professionals, anthropologists and mathematical engineers. He was member of the Research Committee and of the Research Advisory Board of the International Psychoanalytic Association. He was member of the faculty at the Research Training Program and visiting professor at the University College London (2007-2015). In both psychoanalysis and psychiatry, his interests revolve around the conditions for the construction of epistemological as well as methodological pluralism and interdisciplinary research in Mental Health. In this capacity he was invited to be one of the members of the committee of the International Psychoanalytical Association for the integration of theories in psychoanalysis (2008-2012).Alberto Botto, MD, Ph.D., is assistant professor of psychiatry at the Department of Psychiatry and Mental Health, University of Chile, Santiago (Eastern Campus); trained psychotherapist and researcher at the Millennium Institute for Research on Depression and Personality (MIDAP). Visiting professor Postgraduate Degree in Dynamic Psychotherapy (UPD) at the Instituto Psiquiátrico Dr. José Horwitz Barak. Visiting Professor Doctorate in Developmental Sciences and Psychopathology, Universidad del Desarrollo. Professor of Diploma in psychotherapy research for mental health professionals, Universidad Diego Portales. He is a member of the Society for Psychotherapy Research (SPR), International Association for Relational Psychoanalysis and Psychotherapy (IARPP), Sociedad Chilena para el Desarrollo de la Psiquiatría (SODEPSI), Asociación Psicoanalítica de Santiago (APSAN). He has been General Editor of the journal Gaceta de Psiquiatría Universitaria and past president of Sociedad Chilena para el Desarrollo de la Psiquiatría (SODEPSI). Author of the books: Mood Stabilizers (Ediciones Gaceta de Psiquiatría Universitaria. Temas y Controversias. Santiago, 2007) and Escorzo. Ensayos sobre psiquiatría y psicoterapia (Sodepsi Ediciones, Santiago, 2016). He is also co-author with Julia Acuña and Juan Pablo Jiménez of the book Psiquiatría para Atención Primaria y el Médico General.Depresión, ansiedad y somatización (Editorial Mediterráneo, Santiago de Chile, 2009). Currently, his research interest is focused on the epistemological and psychopathological aspects of mood disorders and specifically in the study of gene-culture interaction in depressive symptomatology and subjective well-being in Chile.Peter Fonagy, OBE, FMedSci, FBA, FAcSS, PhD, is Professor of Contemporary Psychoanalysis and Developmental Science and Director of the Division of Psychology and Language Sciences, University College London (UCL), Chief Executive, Anna Freud National Centre for Children and Families, and Programme Director, Mental Health and Wellbeing Programme, UCLPartners. His clinical interests centre on issues of mentalization theory and research, borderline psychopathology, violence and early attachment relationships. His work attempts to integrate empirical research with psychoanalytic theory. With an H-Index of 156 (Google Scholar), 85 (Scopus), – 20 publications over 1,000 citations –, he has published 609 original peer-reviewed papers and articles, 284 chapters, has authored 21 books and edited 18. He has received numerous awards for his contributions to clinical psychology and psychoanalysis, including the Order of the British Empire (OBE) and the Wiley Prize of the British Academy for Lifetime Achievements. He has had multiple professional responsibilities in the British Health Care System where he is Senior Clinical Advisor for children’s mental health and is leading task groups on numerous specific problems.

• Part I: Epistemology, Epidemiology, Psychopathology and History of Depression.- Chapter 1. The Study of Depression in the Frame of the new Research Paradigm in Psychiatry.- Chapter 2. Psychopathology of Depression in the Spectrum of Mood Disorders.- Chapter 3. Epidemiology of Depression: Burden of Disease, Trends, and the Con-tributions of Social Epidemiology to the Study of its Causes.- Chapter 4. Idioms of Depression in Contemporary Individualistic Societies: Unit-ed States and Chile.- Part II: Etiopathogenic Theories and Models.- Chapter 5. Contemporary Psychodynamic Theories on Depression.- Chapter 6. Theory and Interventions in Cognitive Behavioral Therapy for Depression.- Chapter 7. Genetic and Epigenetic Determinants of Depression: From Basic Re-search to Translational Medicine.- Chapter 8. Neurobiology of Depression.- Chapter 9. A Dimensional and Dynamic Approach to the Neurobiology of Mood Disorders: On Intermediate Phenotypes and their Interaction with Early Stress.- 10. Psychophysiology and Psychoneuroendocrinology of Stress and Re-ward in Depression.- Chapter 11. Depression and (Expert) Culture: Psychiatric, Regulatory and Moral Frameworks Underpinning the Absence of Depression in Occupation-al Health in Chile.- Chapter 12. Poverty, Social Inequity, and Depression.- Part III: Evolution and Development as an Integrating Framework.- Chapter 13. An Integrative Developmental Psychopathology Approach to Depression.- Chapter 14. Depression and Personality Dysfunction: Moving from Descriptive Comorbidity to the Identification of Common Intermediate Phenotypes.- Chapter 15. Gender and Depression: Women, Transgender and Gender Non-Conforming Depression.- Part IV: Clinical Practice as a Meeting Place for Etiopathogenic Models.- Chapter 16. Models in Depression and Clinical Judgment, or how to use Different Etiopathogenic Models with a Particular Patient.