Novel Synthetic Drugs in Migraine

Paolo Martelletti is Professor of Internal Medicine at the University 'La Sapienza' of Rome, and Director of the Regional Reference Headache Center at the Sant'Andrea University Hospital in Rome, Italy. He is now developing new research avenues for the study of factors for chronicity, comorbidities, and aspects of health economics in primary headaches; elaboration of rehabilitation protocols in patients with secondary headache as a consequence of medication overuse; study of innovative therapies for the acute treatment and prophylaxis of primary headaches. He is Editor of the Springer Headache book series and Editor-in-Chief of the Journal of Headache and Pain and Editor-in-Chief of Springer Nature Comprehensive Clinical Medicine.​Lars Edvinsson is Professor of Internal Medicine at the  Faculty of Medicine, Lund University Hospital, Sweden. He is a leading expert in the field of  cerebral circulation and  migraine and is  world recognized for his work on vascular innervation and receptor regulation. His extensive research has been a major contributor to what is known about the roles of the cerebral vasculature in health and diseases such as stroke and primary headaches. Recently, his ground-breaking work on the sensory system has resulted in new medicine being introduced small molecular CGRP-blockers for acute attacks and antibodies towards CGRP or CGRP-receptors as prophylaxis chronic migraine.

• Preface.-Foreword.-1. Novel Pharmacological Targets of Migraine: An Overview​.-2. Molecular and cellular mechanisms of CGRP antagonists.-3. Atogepant.-4. Ubrogepant.-5. Rimegepant.-6. Zavegepant.-7. Molecular mechanisms of 5-HT1F receptor agonists.-8. Lasmitidan.-9. Update on old and current targets for anti-migraine therapies