Élodie Giroux is Professor of philosophy of medicine at the philosophy department of Jean Moulin Lyon 3 University and researcher at the Lyon Institute of Philosophical Research (Irphil). Her research interests and her main publications focus on the history of risk factor epidemiology, philosophy of epidemiology, causation in medicine and public health, health and disease concepts, and more recently precision medicine and integrative research in environmental health and exposomics.Francesca Merlin is Permanent research fellow in philosophy of biology at CNRS. She holds a PhD in Philosophy (University of Paris 1 Panthéon Sorbonne, 2009). Her research focuses on ontological and epistemological issues raised by central concepts in biology such as chance and probability, inheritance and epigenetics, in various biological disciplines. She is currently the leader of the ANR EnviroBioSoc project about the plurality of ways the environment is conceived throughout biomedical and social sciences studying environmentally induced diseases.Yohan Fayet is Health Geographer (PhD) at the Human and Social Sciences Departement of the Centre Léon Bérard (Comprehensive Cancer Center in Lyon, France). He is interested in the analysis of spatial inequalities in health, through the multiple impact of physical, social and medical environments on health outcomes. He focuses on spatial inequalities in cancer and analyses potential challenges raised by innovations in oncology.

• PART 1: Articulating the social and the biological.- Chapter 1: The turn towards ‘the biosocial’ in epigenetics. Ontological, epistemic and socio-political considerations.- Chapter 2: Socio-markers and the trace of information transmission.- Chapter 3: What’s Wrong with the Biologization of Social Inequalities in Health? A history of social epidemiology and its moral economy of objectivity.- Part 2: Integration in environmental health and exposome research: epistemological issues.- Chapter 4: Which Integration for Health? Comparing Integrative Approaches for Epidemiology.- Chapter 5: A Critical Assessment of Exposures Integration in Exposome Research.- Chapter 6: From exposome to pathogenic niche. Looking for an operational account of the environment in health studies.- PART 3: The case of exposome research: practical and disciplinary issues.- Chapter 7: Place of integrative approaches in the study of spatial dimension of health outcomes.- Chapter 8: Exposome and the social sciences: the case of systemic diseases.- Chapter 9: The exposome research program and nutrition: the example of celiac disease.

Élodie Giroux is Professor of philosophy of medicine at the philosophy department of Jean Moulin Lyon 3 University and researcher at the Lyon Institute of Philosophical Research (Irphil). Her research interests and her main publications focus on the history of risk factor epidemiology, philosophy of epidemiology, causation in medicine and public health, health and disease concepts, and more recently precision medicine and integrative research in environmental health and exposomics.Francesca Merlin is Permanent research fellow in philosophy of biology at CNRS. She holds a PhD in Philosophy (University of Paris 1 Panthéon Sorbonne, 2009). Her research focuses on ontological and epistemological issues raised by central concepts in biology such as chance and probability, inheritance and epigenetics, in various biological disciplines. She is currently the leader of the ANR EnviroBioSoc project about the plurality of ways the environment is conceived throughout biomedical and social sciences studying environmentally induced diseases.Yohan Fayet is Health Geographer (PhD) at the Human and Social Sciences Departement of the Centre Léon Bérard (Comprehensive Cancer Center in Lyon, France). He is interested in the analysis of spatial inequalities in health, through the multiple impact of physical, social and medical environments on health outcomes. He focuses on spatial inequalities in cancer and analyses potential challenges raised by innovations in oncology.

• PART 1: Articulating the social and the biological.- Chapter 1: The turn towards ‘the biosocial’ in epigenetics. Ontological, epistemic and socio-political considerations.- Chapter 2: Socio-markers and the trace of information transmission.- Chapter 3: What’s Wrong with the Biologization of Social Inequalities in Health? A history of social epidemiology and its moral economy of objectivity.- Part 2: Integration in environmental health and exposome research: epistemological issues.- Chapter 4: Which Integration for Health? Comparing Integrative Approaches for Epidemiology.- Chapter 5: A Critical Assessment of Exposures Integration in Exposome Research.- Chapter 6: From exposome to pathogenic niche. Looking for an operational account of the environment in health studies.- PART 3: The case of exposome research: practical and disciplinary issues.- Chapter 7: Place of integrative approaches in the study of spatial dimension of health outcomes.- Chapter 8: Exposome and the social sciences: the case of systemic diseases.- Chapter 9: The exposome research program and nutrition: the example of celiac disease.

Élodie Giroux is Professor of philosophy of medicine at the philosophy department of Jean Moulin Lyon 3 University and researcher at the Lyon Institute of Philosophical Research (Irphil). Her research interests and her main publications focus on the history of risk factor epidemiology, philosophy of epidemiology, causation in medicine and public health, health and disease concepts, and more recently precision medicine and integrative research in environmental health and exposomics.Francesca Merlin is Permanent research fellow in philosophy of biology at CNRS. She holds a PhD in Philosophy (University of Paris 1 Panthéon Sorbonne, 2009). Her research focuses on ontological and epistemological issues raised by central concepts in biology such as chance and probability, inheritance and epigenetics, in various biological disciplines. She is currently the leader of the ANR EnviroBioSoc project about the plurality of ways the environment is conceived throughout biomedical and social sciences studying environmentally induced diseases.Yohan Fayet is Health Geographer (PhD) at the Human and Social Sciences Departement of the Centre Léon Bérard (Comprehensive Cancer Center in Lyon, France). He is interested in the analysis of spatial inequalities in health, through the multiple impact of physical, social and medical environments on health outcomes. He focuses on spatial inequalities in cancer and analyses potential challenges raised by innovations in oncology.

• PART 1: Articulating the social and the biological.- Chapter 1: The turn towards ‘the biosocial’ in epigenetics. Ontological, epistemic and socio-political considerations.- Chapter 2: Socio-markers and the trace of information transmission.- Chapter 3: What’s Wrong with the Biologization of Social Inequalities in Health? A history of social epidemiology and its moral economy of objectivity.- Part 2: Integration in environmental health and exposome research: epistemological issues.- Chapter 4: Which Integration for Health? Comparing Integrative Approaches for Epidemiology.- Chapter 5: A Critical Assessment of Exposures Integration in Exposome Research.- Chapter 6: From exposome to pathogenic niche. Looking for an operational account of the environment in health studies.- PART 3: The case of exposome research: practical and disciplinary issues.- Chapter 7: Place of integrative approaches in the study of spatial dimension of health outcomes.- Chapter 8: Exposome and the social sciences: the case of systemic diseases.- Chapter 9: The exposome research program and nutrition: the example of celiac disease.