Randy Q. Cron, MD, PhD,University of Alabama at BirminghamProfessor of Pediatrics and MedicineBirmingham, AlabamaUSAEdward M. Behrens, MD                 University of Pennsylvania Perelman School of MedicinePerelman School of MedicinePhiladelphia, PennsylvaniaUSA

• 1. Cytokines in cytokine storm syndromes.- 2. History of HLH.- 3. The history of macrophage activation syndrome in autoimmune diseases.- 4. Clinical features of cytokine storm syndromes.- 5. Laboratory features and pathology of cytokine storm syndromes.- 6. Criteria for cytokine storm syndromes.- 7. Familial HLH genetics.- 8. Secondary HLH genetics.- 9. Genetics of macrophage activation syndrome in systemic juvenile idiopathic arthritis.- 10. CD8+ T cell biology in cytokine storm syndromes.- 11. Immunology of cytokine storm syndromes: Natural killer cells.- 12. Myeloid cells in the immunopathogenesis of cytokine storm syndrome.- 13. Cytokine storm.- 14. Primary immunodeficiencies.- 15. Infectious triggers of cytokine storm syndromes: Herpes virus family (non-EBV).- 16. CSS associated with Epstein Barr Virus.- 17. Hemorrhagic Fever and other viruses.- 18. Cytokine storm syndrome as a manifestation of primary HIV infection.- 19. Bacteria-associated cytokine storm syndrome.- 20. Zoonoticbacterial infections triggering cytokine storm syndrome.- 21. Parasitic and fungal triggers.- 22. COVID-19 pneumonia and cytokine storm syndrome.- 23. Cytokine storm associated with Systemic Juvenile Idiopathic Arthritis.- 24. Systemic lupus erythematosus.- 25. Kawasaki disease.- 26. The intersections of autoinflammation and cytokine storm.- 27. Other rheumatic triggers.- 28. Multisystem Inflammatory Syndrome in children.- 29. Hemophagocytic lymphohistiocytosis in the context of hematological malignancies and solid tumors.- 30. Cytokine storm and sepsis-induced Multiple Organ Dysfunction Syndrome.- 31. The cytokine storm of Multicentric Castleman Disease.- 32. Cytokine storm syndromes associated with pregnancy and therapeutics.- 33. fHLH models.- 34. sHLH models.- 35. Etoposide therapy of CSS.- 36. IL-1 family blockade.- 37. IL-6 blockade.- 38. IFNy blockade.- 39. JAK inhibitors.- 40. Other immunomodulatory HLH treatments.- 41. Salvage therapy for HLH.

Randy Q. Cron, MD, PhD,University of Alabama at BirminghamProfessor of Pediatrics and MedicineBirmingham, AlabamaUSAEdward M. Behrens, MD                 University of Pennsylvania Perelman School of MedicinePerelman School of MedicinePhiladelphia, PennsylvaniaUSA

• 1. Cytokines in cytokine storm syndromes.- 2. History of HLH.- 3. The history of macrophage activation syndrome in autoimmune diseases.- 4. Clinical features of cytokine storm syndromes.- 5. Laboratory features and pathology of cytokine storm syndromes.- 6. Criteria for cytokine storm syndromes.- 7. Familial HLH genetics.- 8. Secondary HLH genetics.- 9. Genetics of macrophage activation syndrome in systemic juvenile idiopathic arthritis.- 10. CD8+ T cell biology in cytokine storm syndromes.- 11. Immunology of cytokine storm syndromes: Natural killer cells.- 12. Myeloid cells in the immunopathogenesis of cytokine storm syndrome.- 13. Cytokine storm.- 14. Primary immunodeficiencies.- 15. Infectious triggers of cytokine storm syndromes: Herpes virus family (non-EBV).- 16. CSS associated with Epstein Barr Virus.- 17. Hemorrhagic Fever and other viruses.- 18. Cytokine storm syndrome as a manifestation of primary HIV infection.- 19. Bacteria-associated cytokine storm syndrome.- 20. Zoonoticbacterial infections triggering cytokine storm syndrome.- 21. Parasitic and fungal triggers.- 22. COVID-19 pneumonia and cytokine storm syndrome.- 23. Cytokine storm associated with Systemic Juvenile Idiopathic Arthritis.- 24. Systemic lupus erythematosus.- 25. Kawasaki disease.- 26. The intersections of autoinflammation and cytokine storm.- 27. Other rheumatic triggers.- 28. Multisystem Inflammatory Syndrome in children.- 29. Hemophagocytic lymphohistiocytosis in the context of hematological malignancies and solid tumors.- 30. Cytokine storm and sepsis-induced Multiple Organ Dysfunction Syndrome.- 31. The cytokine storm of Multicentric Castleman Disease.- 32. Cytokine storm syndromes associated with pregnancy and therapeutics.- 33. fHLH models.- 34. sHLH models.- 35. Etoposide therapy of CSS.- 36. IL-1 family blockade.- 37. IL-6 blockade.- 38. IFNy blockade.- 39. JAK inhibitors.- 40. Other immunomodulatory HLH treatments.- 41. Salvage therapy for HLH.

Randy Q. Cron, MD, PhD,University of Alabama at BirminghamProfessor of Pediatrics and MedicineBirmingham, AlabamaUSAEdward M. Behrens, MD                 University of Pennsylvania Perelman School of MedicinePerelman School of MedicinePhiladelphia, PennsylvaniaUSA

• 1. Cytokines in cytokine storm syndromes.- 2. History of HLH.- 3. The history of macrophage activation syndrome in autoimmune diseases.- 4. Clinical features of cytokine storm syndromes.- 5. Laboratory features and pathology of cytokine storm syndromes.- 6. Criteria for cytokine storm syndromes.- 7. Familial HLH genetics.- 8. Secondary HLH genetics.- 9. Genetics of macrophage activation syndrome in systemic juvenile idiopathic arthritis.- 10. CD8+ T cell biology in cytokine storm syndromes.- 11. Immunology of cytokine storm syndromes: Natural killer cells.- 12. Myeloid cells in the immunopathogenesis of cytokine storm syndrome.- 13. Cytokine storm.- 14. Primary immunodeficiencies.- 15. Infectious triggers of cytokine storm syndromes: Herpes virus family (non-EBV).- 16. CSS associated with Epstein Barr Virus.- 17. Hemorrhagic Fever and other viruses.- 18. Cytokine storm syndrome as a manifestation of primary HIV infection.- 19. Bacteria-associated cytokine storm syndrome.- 20. Zoonoticbacterial infections triggering cytokine storm syndrome.- 21. Parasitic and fungal triggers.- 22. COVID-19 pneumonia and cytokine storm syndrome.- 23. Cytokine storm associated with Systemic Juvenile Idiopathic Arthritis.- 24. Systemic lupus erythematosus.- 25. Kawasaki disease.- 26. The intersections of autoinflammation and cytokine storm.- 27. Other rheumatic triggers.- 28. Multisystem Inflammatory Syndrome in children.- 29. Hemophagocytic lymphohistiocytosis in the context of hematological malignancies and solid tumors.- 30. Cytokine storm and sepsis-induced Multiple Organ Dysfunction Syndrome.- 31. The cytokine storm of Multicentric Castleman Disease.- 32. Cytokine storm syndromes associated with pregnancy and therapeutics.- 33. fHLH models.- 34. sHLH models.- 35. Etoposide therapy of CSS.- 36. IL-1 family blockade.- 37. IL-6 blockade.- 38. IFNy blockade.- 39. JAK inhibitors.- 40. Other immunomodulatory HLH treatments.- 41. Salvage therapy for HLH.