This book constitutes the proceedings of the 22nd International Conference on Scientific Computing and Bioinformatics, CSC 2024, and the 25th International Conference on Computational Biology, BIOCOMP 2024, held as part of the 2024 World Congress in Computer Science, Computer Engineering and Applied Computing, in Las Vegas, USA, during July 22 to July 25, 2024.The proceedings include 25 papers from CSC 2024, which have been selected from a total of 128 submissions, and 27 papers from BIOCOMP 2024, that have been selected from 27 submissions. The papers have been organized in topical sections as follows: Military and defence modeling and simulation; scientific computing and applications; and bioinformatics and computational biology.