Francesca De Luzi is a postdoctoral researcher at Sapienza Università di Roma, Italy. Her recent research projects have focused on the use of AI techniques, particularly through the development of writing assistants to support operators in performing complex linguistic tasks by leveraging large language models.Flavia Monti is a postdoctoral researcher at Sapienza Università di Roma, Italy. Her research interests focus on Industry 4.0 and smart manufacturing, particularly the integration of computer vision, machine learning, and generative artificial intelligence to improve production quality, reduce costs, increase machinery uptime, and achieve zero-defect manufacturing.Massimo Mecella is a full professor at Sapienza Università di Roma, where he conducts research in the fields of information systems engineering, service-oriented computing, mobile and pervasive computing, process management, data and process mining, big data analytics and human-computer interaction, focusing on smart applications, environments and communities. He was the General Chair of CAiSE 2019, BPM 2021, and ICSOC 2023. In 2025, he is the PC co-Chair of IEEE CAI 2025. He is currently a member of the Steering Committees of the conference series CAiSE, ICSOC and SummerSOC.

• 1. Introduction.- 2. History of LLMs.- 3. LLMs for Dummies.- 4. A Reference Framework for Information Systems.- 5. Exploring Large Language Models in Information Systems: A Survey.- 6. Programming LLMs.- 7. Retrieval Augmented Generation.- 8. Large Language Model Agents.- 9. Applications of Large Language Models in Information Systems.- 10. Ethics and Governance of Large Language Models.- 11. Epilogue.

Francesca De Luzi is a postdoctoral researcher at Sapienza Università di Roma, Italy. Her recent research projects have focused on the use of AI techniques, particularly through the development of writing assistants to support operators in performing complex linguistic tasks by leveraging large language models.Flavia Monti is a postdoctoral researcher at Sapienza Università di Roma, Italy. Her research interests focus on Industry 4.0 and smart manufacturing, particularly the integration of computer vision, machine learning, and generative artificial intelligence to improve production quality, reduce costs, increase machinery uptime, and achieve zero-defect manufacturing.Massimo Mecella is a full professor at Sapienza Università di Roma, where he conducts research in the fields of information systems engineering, service-oriented computing, mobile and pervasive computing, process management, data and process mining, big data analytics and human-computer interaction, focusing on smart applications, environments and communities. He was the General Chair of CAiSE 2019, BPM 2021, and ICSOC 2023. In 2025, he is the PC co-Chair of IEEE CAI 2025. He is currently a member of the Steering Committees of the conference series CAiSE, ICSOC and SummerSOC.

• 1. Introduction.- 2. History of LLMs.- 3. LLMs for Dummies.- 4. A Reference Framework for Information Systems.- 5. Exploring Large Language Models in Information Systems: A Survey.- 6. Programming LLMs.- 7. Retrieval Augmented Generation.- 8. Large Language Model Agents.- 9. Applications of Large Language Models in Information Systems.- 10. Ethics and Governance of Large Language Models.- 11. Epilogue.