This book constitutes the proceedings of the 10th International Conference on Digital Economy, ICDEc 2025, held in Tunis, Tunisia, during May 15-17, 2025.The 31 full papers presented in this volume were carefully reviewed and selected from 94 submissions. They were organized in the following topical sections: Digital Governance and Public Policy; Cross-Domain AI Innovations: From Autonomous Systems to Health and Finance; Social Media, Responsibility and Digital Leadership; Informal Markets and Platform Economies; AI-Driven Insights and Next-Gen Marketing Analytics; Digital Transformation in Finance: Taxation, Payment Resilience, and E-Finance Trends; Trust, Privacy and Security in the Digital Economy; and Smart Infrastructure and AI Readiness.