This 2-volume set constitutes the post proceedings of the 22nd IFIP WG 5.1 International Conference on Product Lifecycle Management, PLM 2025, which took place in Seville, Spain, July 2025.The 79 full papers presented in this volume were carefully reviewed and selected from 143 submissions. The papers are organized in the following topical sections:Part I: Digital Twin and Smart Systems; AI and Data-Driven Innovation; Sustainable and Circular Product Lifecycle.Part II: Model-Based Engineering (MBE) and System Engineering; Organizational Transformation and Strategy; Interoperability and Integration Technologies; Human-Centric and Educational Innovation.
