This book constitutes the refereed proceedings of the 5th Latin American Workshop, LAWCN 2025, held in La Plata, Argentina, during November 12–14, 2025.The 6 full papers and 4 short papers presented in this volume were carefully reviewed and selected from 11 submissions. They were organized in the follwing topical sections as follows: Artificial Intelligence and Machine Learning; and Neuroengineering.