This book constitutes the proceedings of the 22nd International Conference on Unconventional Computation and Natural Computation, UCNC 2025, held in Nice, France, during September 1-5, 2025.The 24 full papers and 5 short papers presented in this volume were carefully reviewed and selected from 43 submissions. They focus on current important theoretical and experimental results in Molecular computing, Quantum computing, Optical computing, Chaos computing, Physarum computing, Collision-based computing, Self-assembling and self-organizing systems, Super-Turing computation, Cellular automata, Neural computation, Evolutionary computation, Swarm intelligence, Ant algorithms, Artificial immune systems, Artificial life, Membrane computing, Amorphous computing, Computational systems biology, Computational neuroscience, Synthetic biology, Cellular (in-vivo) computing, and other unconventional and natural models of computation with no limitations on their inspiration and origin.
