This book constitutes the proceedings of the First Interdisciplinary Workshop on Reponsible AI for Value Creation, REPAI-W 2025, which took place in Copenhagen, Denmark, during December 1, 2025. The 6 full papers included in this proceedings were carefully reviewed and selected from 9 submissions. The book also contains one invited paper. They deal with AI solutions over complementary disciplines—such as technical AI development, ethics, law, organizational studies, and value creation—to deepen the understanding of AI’s role in real-world practice and shape its responsible use.