This five-volume set CCIS 2819–2823 constitutes the refereed proceedings of the 4th International Conference on Advancements in Smart Computing and Information Security, ASCIS 2025, held in Rajkot, Gujarat, India, during September 11–13, 2025.The 112 full papers and 25 short papers included in these volumes were carefully reviewed and selected from 579 submissions. They are organized into the following topical sections:Part I, II, III: Artificial Intelligence & Machine LearningPart IV: Cyber SecurityPart V: Smart Computing