This book constitutes the revised selected extended papers of the 8th IEEE Colombian Conference on Applications of Computational Intelligence, ColCACI 2025, held in Armenia, Colombia, during August 27–29, 2025.The 17 full papers were carefully reviewed and selected from 61 submissions. They explore various topics in the area of computational intelligence (CI), such as control applications, microseismical signal analysis, optimization problems, industry, agriculture, and biomedical engineering problems.