This book presents a comprehensive collection of peer-reviewed contributions from the Mediterranean Smart Cities Conference 2025, held in Tetuan and Martil, Morocco.Reflecting the rapid evolution of urban environments driven by digital transformation, this book explores smart cities as integrated, data-driven, and sustainable systems. It brings together multidisciplinary research and innovative applications from international scholars and practitioners, addressing both technological advancements and real-world urban challenges.This book covers a wide spectrum of cutting-edge topics, including intelligent transportation systems and urban mobility, Internet of Things (IoT) architectures, wireless sensor networks, 5G and beyond communication systems, artificial intelligence and machine learning applications, smart healthcare and digital epidemiology, smart energy systems and smart grids, climate-resilient water management, and urban sustainability. Special emphasis is placed on system-level approaches, real-world applications, and case studies, particularly in emerging and diverse urban contexts.By combining theoretical developments, algorithmic innovations, and applied research, this book serves as a valuable reference for researchers, postgraduate students, engineers, urban planners, policymakers, and industry professionals engaged in the design, deployment, and governance of smart and sustainable cities.