This two volume set constitutes the refereed proceedings of the 22nd International Conference, ITS 2026, held in Pafos, Cyprus, during June 1–5, 2026.The 30 full papers, 30 short papers and 11 posters included in this volume were carefully reviewed and selected from 103 submissions. They are grouped into the following topics: Intelligent Tutoring Systems and Adaptivel Learning Agents; Human-Ai Interaction, Engagement & Gamification; Learning Analytics and Knowledge for Adaptive Intelligence; Immersive Ecosystems, Digital Twins & the Metaverse; Language, Communication & Generative AI for Learning.