This bookconstitutes the revised selected papers of the 10th Italian Workshop onAdvances in Artificial Life, Evolutionary Computation and Systems Chemistry,WIVACE 2015, held at Bari, Italy, in September 2015.The 18papers presented have been thoroughly reviewed and selected from 45submissions. They cover the following topics: evolutionary computation,bioinspired algorithms, genetic algorithms, bioinformatics and computationalbiology, modeling and simulation of artificial and biological systems, complexsystems, synthetic and systems biology, systems chemistry.