IgE Antibodies: Generation and Function

AvJuan J. Lafaille,Maria A. Curotto de Lafaille

Häftad, Engelska, 2016

Del i serien Current Topics in Microbiology and Immunology

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Beskrivning

This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.

Produktinformation

Utgivningsdatum:2016-10-29
Mått:155 x 235 x 10 mm
Vikt:260 g
Format:Häftad
Språk:Engelska
Serie:Current Topics in Microbiology and Immunology
Antal sidor:152
Förlag:Springer International Publishing AG
ISBN:9783319358888

Utforska kategorier

Patologi inom Medicin
Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Recensioner i media

"This book is a comprehensive, ideal resource for the allergologist, internist/general practitioner, oncologist, pediatrician, as well as the clinical laboratory-based allergologist and immunologist. Reading this book helps us review the basics, recognizing the role of the high affinity IgE receptor and all the surrounding characteristics that shape the allergic response. Most importantly, this book delves into the new applications of IgE-based therapeutics for helminth infections and cancer." (Paola de Baro-Alvarez, World Allergy Organization WAO, worldallergy.org, April, 2016)

Innehållsförteckning

Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses.- Molecular Mechanisms of IgE Class Switch Recombination.- Anti-IgE Therapy: Clinical Utility and Mechanistic Insights.- New Insights on the Signaling and Function of the High Affinity Receptor for IgE.- Helminth-Induced IgE and Protection Against Allergic Disorders.- IgE Immunotherapy Against Cancer.

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