Free Fatty Acid Receptors

Inbunden, Engelska, 2017

Del 236 i serien Handbook of Experimental Pharmacology

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Beskrivning

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Produktinformation

Utgivningsdatum:2017-02-17
Mått:155 x 235 x 19 mm
Vikt:613 g
Format:Inbunden
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:256
Upplaga:17001
Förlag:Springer International Publishing AG
ISBN:9783319506920

Utforska kategorier

Fysiologi inom Medicin
Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Innehållsförteckning

Ligands at Free Fatty Acid Receptor 1 (GPR40).- Ligands at Free Fatty Acid Receptor 2/3 (GPR43)/GPR41.- Ligands at GPR84.- Ligands at Free Fatty Acid Receptor 4 (GPR120).- Homology modelling of FFA receptors.- Sensors for FFA receptors.- Key questions for translation of FFA receptors from pharmacology to medicines.- Polymorphic variation in FFA receptors. Functions and consequences.- The role and future of FFA1 as a therapeutic target.- Gut hormone regulation and secretion via FFA1 and FFA4.- The role of FFA2 and FFA3 in metabolic regulation.- Anti-inflammatory and insulin sensitizing effects of free fatty acid receptors.- Free Fatty Acid receptors and cancer.