Molecular Determinants of Head and Neck Cancer

Barbara Burtness, M.D. is Professor of Medicine, Yale University School of Medicine and Co-Leader, Developmental Therapeutics Program, Yale Cancer Center. As Chair of the Head and Neck Committee in Eastern Cooperative Oncology Group and a member of the NCI Head and Neck Steering Committee, she helps shape the national agenda for research on all stages of head and neck cancer.Erica Golemis, Ph.D. is the Deputy Chief Scientific Officer and Co-leader of the Program in Molecular Therapeutics at the Fox Chase Cancer Center. Her research seeks to define the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to drugs, with the ultimate goal of inhibiting these processes to effect disease control and cure.

“The book is intended primarily for clinicians, fellows, interns, and trainees, but medical students who may be interested in head and neck cancer but face the challenge of updating themselves on the latest innovations may also find this book very useful. … this is an informative and authoritative book on the subject that includes experiences from clinicians and scientists working on head and neck cancer at some of the most renowned cancer centers in the world.” (Ravi Salgia, Doody's Book Reviews, March, 2019)

• - Overview: The Pathobiology of Head and Neck Cancer. - Targeting the ErbB Family in Head and Neck Cancer. - c-MET in Head and Neck Squamous Cell Carcinoma. - Transforming Growth Factor Beta (TGF-β) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC). - The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma. - Jak/STAT Signaling in Head and Neck Cancer. - Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC). - Role of the NOTCH Signaling Pathway in Head and Neck Cancer. - P53 in Head and Neck Squamous Cell Carcinoma. - APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck. - The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma. - Epigenetic Changes and Epigenetic Targets in Head and Neck Cancer. - Inflammation and Head and Neck Squamous Cell Carcinoma. - Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC). - The Clinical Impact of Hypoxia in Head and Neck Squamous Cell Carcinoma. - Angiogenesis and Anti-angiogenic Therapy in Head and Neck Cancer. - FAK as a Target for Therapy in Head and Neck Cancer. - Diversity of Wnt/β-Catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-to-Mesenchymal Transition, and Tumor Microenvironment. - Hyaluronan-Mediated CD44 Signaling Activates Cancer Stem Cells in Head and Neck Cancer. - Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer. - Treatment Paradigms in HPV-Associated SCCHN.