Cellular Ageing and Replicative Senescence

Häftad, Engelska, 2018

Del 4 i serien Healthy Ageing and Longevity

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Beskrivning

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer.

Produktinformation

Utgivningsdatum:2018-05-26
Mått:155 x 235 x 21 mm
Vikt:563 g
Format:Häftad
Språk:Engelska
Serie:Healthy Ageing and Longevity
Antal sidor:364
Förlag:Springer International Publishing AG
ISBN:9783319799124

Utforska kategorier

Cellbiologi inom Naturvetenskap och teknik
Geriatrik inom Medicin
Biologi inom Naturvetenskap och teknik

Innehållsförteckning

Preface.- Section I History and origins.- Origins of the Hayflick system, the phenomenon and the limit.- Early testing and development of the Hayflick system.- Section II Serial passaging and progressive changes.- Slowing down of the cell cycle.- Ageing of cells in the centenarians and long-lived .- Aging of the stem cells.- Aging and senescence in the immune cells in vitro and in vivo.- Accelerated cellular aging in progeroid syndromes.- Telomere and genomic instability.- Mechanistic explanation for cellular aging in vitro: the commitment theory.- Modelling cellular aging senescence.- Section-III Regulation, and senescence.- Cell cycle checkpoints and regulators of senescence.- Oxidative stress and cellular ageing.- Biomarkers of replicative senescence revisited.- Cellular aging and tumour regulation.- Declining Protein turnover and degradation.- Section IV Modulating the system.- Stress induced premature senescence (SIPS).- Mild stress-induced hormesis.- Food, hormones and growth factors in cellular aging.- sncRNAs in cellular aging and senescence.- Elimination of senescent cells for rejuvenation.- Section-V RECAPITULATION.- The past, present and the future of cellular aging and replicative senescence.- Index.