Charles R. Scoggins, University of Louisville, School of Medicine, 315 E. Broadway, Suite 303, 40202 Louisville, KY, USA, e-mail: charles.scoggins@louisville.eduChandrajit P. Raut, Brigham & Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Department of Surgery, 75 Francis St., Boston, MA, USA, 02115 e-mail: craut@bwh.harvard.eduJohn T. Mullen, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 7B, Boston, MA  02114, E-mail:  jmullen@mgh.harvard.edu

• Etiology/Epidemiology.- Pathology.- Molecular Genetics of GIST.- Pediatric GIST/Inheritable Disease.- Natural History.- Radiographic Imaging.- Endoscopic Evaluation.- Prognostic Factors for Localized Disease.- Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection.- Surgery for Localized GIST.- Minimally Invasive Surgery for GIST.- Neoadjuvant Rx and Surgical Consolidation.- Imatinib.- Management of Locally Advanced GIST.- Prognostic Factors for Advanced GIST.- Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy.- Surgical Debulking of Metastatic GIST.- Liver Resection/Ablation of Metastatic GIST.- Palliative Care.

Charles R. Scoggins, University of Louisville, School of Medicine, 315 E. Broadway, Suite 303, 40202 Louisville, KY, USA, e-mail: charles.scoggins@louisville.eduChandrajit P. Raut, Brigham & Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Department of Surgery, 75 Francis St., Boston, MA, USA, 02115 e-mail: craut@bwh.harvard.eduJohn T. Mullen, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 7B, Boston, MA  02114, E-mail:  jmullen@mgh.harvard.edu

• Etiology/Epidemiology.- Pathology.- Molecular Genetics of GIST.- Pediatric GIST/Inheritable Disease.- Natural History.- Radiographic Imaging.- Endoscopic Evaluation.- Prognostic Factors for Localized Disease.- Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection.- Surgery for Localized GIST.- Minimally Invasive Surgery for GIST.- Neoadjuvant Rx and Surgical Consolidation.- Imatinib.- Management of Locally Advanced GIST.- Prognostic Factors for Advanced GIST.- Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy.- Surgical Debulking of Metastatic GIST.- Liver Resection/Ablation of Metastatic GIST.- Palliative Care.

Charles R. Scoggins, University of Louisville, School of Medicine, 315 E. Broadway, Suite 303, 40202 Louisville, KY, USA, e-mail: charles.scoggins@louisville.eduChandrajit P. Raut, Brigham & Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Department of Surgery, 75 Francis St., Boston, MA, USA, 02115 e-mail: craut@bwh.harvard.eduJohn T. Mullen, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 7B, Boston, MA  02114, E-mail:  jmullen@mgh.harvard.edu

• Etiology/Epidemiology.- Pathology.- Molecular Genetics of GIST.- Pediatric GIST/Inheritable Disease.- Natural History.- Radiographic Imaging.- Endoscopic Evaluation.- Prognostic Factors for Localized Disease.- Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection.- Surgery for Localized GIST.- Minimally Invasive Surgery for GIST.- Neoadjuvant Rx and Surgical Consolidation.- Imatinib.- Management of Locally Advanced GIST.- Prognostic Factors for Advanced GIST.- Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy.- Surgical Debulking of Metastatic GIST.- Liver Resection/Ablation of Metastatic GIST.- Palliative Care.