Inflammation-Associated Depression: Evidence, Mechanisms and Implications

“This book covers important and growing field of knowledge associated with the role of inflammation in depression. … The book is well written and presented with many diagrams and illustrations. It covers the gap in this area of psychiatry research and potential for clinical practice and will be of interest for clinicians and researchers worldwide.” (Branka Aukst Margetic, Alcoholism and Psychiatry Research, Vol. 54 (01), June, 2018)“The authors describe the current research data surrounding the role of inflammation and its impact on depression. … Each chapter begins with an abstract, identified keywords, and an outline of the chapter. Most chapters contain helpful graphics and conclude withreferences. … To my knowledge, this is the first book focused solely on the role of inflammation in psychiatry, which was confirmed by a quick internet search.” (Aaron Plattner, Doody’s Book Reviews, April, 2017)

• Section 1: Evidence for inflammation-associated depression.- Evidence for inflammation-associated depression.- Role of inflammation in the development of neuropsychiatric symptom domains.- Inflammation-associated comorbidity.- Section 2: Mechanisms of inflammation-associated depression.- Mechanisms of inflammation-associated depression Immune-to-brain communication pathways and cytokines.- Immune-to-brain communication pathways.- Mechanisms of inflammation-associated depression.- Role of the kynurenine metabolism pathway.- Depression in autoimmune diseases.- Stress-induced microglia activation.- Inflammation effects on brain glutamate.- The role of dopamine.- Brain structures implicated in inflammation-associated depression.- Role of kynurenine metabolism pathway.- Suicidality. Section 3: Clinical implications of inflammation-associated depression.- The promise and limitations of anti-inflammatory agents.- Are non-steroidal anti-inflammatory drugs.- Does diet matter?- Role of neuroimunological factors.