Pathology of the Placenta

Dr. T. Yee Khong, MBChB, MD, MSc, FRCPath, FRCPA, FAMM, GAICD, is a Consultant Pathologist at SA Pathology, Women’s and Children’s Hospital, Adelaide, Australia. He qualified in medicine from University of Sheffield, UK and did his pathology training at St George’s Hospital Medical School, London and John Radcliffe Hospital, Oxford, UK. He is Professor of Pathology and Obstetrics & Gynaecology, at the University of Adelaide and a former President of the Royal College of Pathologists of Australasia.Dr. Eoghan Mooney, MBChB, MRCPI, FRCPath, FFPath (RCPI), was born in Dublin, Ireland, where he now lives and works. He is a graduate of the National University of Ireland (University College Dublin). Following pathology training in Dublin and in Duke University, North Carolina, USA he completed his Fellowship in Gynaecologic and Breast pathology in the Armed Forces Institute of Pathology, Washington DC. He has been a consultant pathologist for 17 years, based in the National Maternity Hospital and St Vincent’s University Hospital and has published in the area of placental pathology for 20years.Dr. Peter G.J. Nikkels, MD, PhD, is a staff member in the Department of Pathology, University Hospital Utrecht, the Netherlands. He qualified in medicine from Erasmus University Rotterdam, the Netherlands and did his pathology training at the Department of Pathology, University Hospital Groningen, the Netherlands where he became a consultant pathologist. He has published extensively in placental pathology.Dr. Terry K. Morgan, MD, PhD, completed residency training, a surgical pathology fellowship and cytopathology fellowship at Stanford University Medical Center. He is Associate Professor of Pathology and Obstetrics & Gynecology, at the Oregon Health & Science University. He is the director of placental pathology and the focus of his research laboratory is to determine how abnormal blood flow to the placenta leads to common maternal pregnancy complications and fetal programming of adult onset disease in theirprogeny.Dr. Sanne J Gordijn, MD, PhD, completed her residency training inUniversity of Groningen, the Netherlands and is a consultant in obstetrics witha special interest in perinatology. Her research interests are in perinatalautopsy, placental pathology and classification of perinatal mortality.

“This book is intended as a resource for practicing anatomic pathologists in a community or academic hospital setting. As the book provides significant correlation between macroscopic and microscopic findings, it is excellent for pathology residents and/or fellows who may both gross and microscopically evaluate a placental specimen. Additionally, it may serve as an additional reference for clinical obstetricians or pediatricians specializing in neonatology.” (Lauren Stanoszek, Doody's Book Reviews, July 26, 2019)

• Section 1. Background.- Chapter 1. Introduction. An approach to placental pathology.- Chapter 2. Placental Development with Expected Normal Gross and Microscopic Findings.- Chapter 3. Indications for examining the placenta.- Section 2. Gross examination.- Chapter 4. Gross examination.- Chapter 5. Placental Weight, Shape, and Gross Vascular Morphology.- Section 3. Placental disc: Macroscopically Visible Lesions.- Chapter 6. Infarction.- Chapter 7. Intervillous thrombosis.- Chapter 8. Massive perivillous fibrin deposition, maternal floor infarct.- Chapter 9. Retroplacental haemorrhage, marginal haemorrhage.- Chapter 10. Fetal Vascular Thrombosis.- Chapter 11. Extravillous trophoblast cyst.- Section 4.   Placental disc: Microscopic Lesions.- Chapter 12. Acute Chorioamnionitis.- Chapter 13. Chorionic plate chronic inflammatory lesions including eosinophilic/T-cell chorionic vasculitis.- Chapter 14. Maturity anomalies.- Chapter 15. Distal villous hypoplasia.- Chapter 16. Placental mesenchymal dysplasia.- Chapter 17. Increased syncytial knot formation.- Chapter 18. Persistence of cytotrophoblast.- Chapter 19. Mineralization of trophoblast basement membrane.- Chapter 20. Trophoblast and stroma:  vacuolation – inherited disorder of metabolism.- Chapter 21. Villous oedema.- Chapter 22. Extramedullary haemopoiesis.- Chapter 23. Intravillous haemorrhage.- Chapter 24. Hypervascularity.- Chapter 25. Fetal vascular malperfusion.- Chapter 26. Presence of nucleated red blood cells.- Chapter 27. Fetal vessels: malignancy.- Chapter 28. Acute villitis.- Chapter 29. Chronic villitis.- Chapter 30. Chronic histiocytic intervillositis.- Chapter 31. Intervillous space:  infiltrates.- Chapter 32. Pregnancy-induced uterine vascular remodelling and the pathophysiology of decidual vasculopathy.- Chapter 33. Chronic deciduitis.- Chapter 34. Basal plate myometrial fibres.- Chapter 35. Basal plate laminar necrosis.- Chapter 36. Retroplacental Haematoma/Haemorrhage (RPH).-Chapter 37. Miscellaneous Lesions of the Villous Parenchyma.- Section 5. Amniochorial membranes: Macroscopically Visible Lesions.- Chapter 38. Amniochorial membrane nodules.- Chapter 39. Placental changes in amniotic band sequence, extra-amniotic and extramembranous pregnancy.- Section 6.   Amniochorial membranes: Microscopic Lesions.- Chapter 40. Amnion Transport: Histologic Features.- Chapter 41. Choriodecidual haemosiderin staining.- Chapter 42. Laminar necrosis; membrane chorionic microcysts and chorion nodosum.- Chapter 43. Decidual Vasculopathy .- Chapter 44. Acute inflammation.- Chapter 45. Chronic inflammation.- Section 7. Umbilical cord.- Chapter 46. Umbilical Cord Length.- Chapter 47. Umbilical Cord coiling.- Chapter 48. Cord knots and pseudo-knots.- Chapter 49. Umbilical cord tumours.- Chapter 50. Umbilical Cord Insertion abnormalities.- Chapter 51. Embryonic remnants and pathology.- Chapter 52. Single Umbilical Artery, Supernumerary Vessels, Segmental Thinningof the Umbilical Cord Vessels and Vascular calcifications in umbilical vessels.- Chapter 53. Umbilical cord ulcer.- Chapter 54. Umbilical vascular myonecrosis.- Chapter 55. Inflammation.- Section 8. Clinical correlation, reporting and frontiers.- Chapter 56. Constellations of Pathology in the Placenta and How They Relate to Clinical Conditions.- Chapter 57. The Placental Pathology Report.- Chapter 58. Frontiers.