Molecular System Bioenergetics

Valdur Saks is Professor of Bioenergetics and Biochemistry at the University of Grenoble, France, and Head of the Laboratory of Bioenergetics at the National Institute of Chemical and Biological Physics in Tallinn, Estonia. A graduate of Moscow University, he was the long-time head of the Laboratory of Cardiac Bioenergetics in Moscow, Russia, before taking up his present positions. Professor Saks has authored over 220 scientific publications and has received numerous scientific awards, including the USSR State Prize in Science and the Internatinoal "Research and Development" Award sponsored by the U.N. and UNICEF. He is a member of the International Society for Heart Research and of the American Physiological and Biophysical Societies.

• IntroductionMOLECULAR SYSTEM BIOENERGETICS: BASIC PRINCIPLES, ORGANISATION AND DYNAMICS OF CELLULAR ENERGETICSCellular Energy Metabolism and Integrated Oxidative PhosphorylationOrganization and Regulation of Mitochondrial Oxidative PhosphorylationIntegrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation and Metabolic ChannelingOn the Network Properties of MitochondriaStructural Organization and Dynamics of Mitochondria in the Cells In VivoENERGY TRANSFER NETWORKS, METABOLIC FEEDBACK REGULATION AND MODELING OF CELLULAR ENERGETICSMitochondrial VDAC and its ComplexesPhospho-Creatine Circuit: Integration of Adenylate Kinase, Glycolytic and Glycogenolytic Circuits in Cellular EnergeticsSignaling by AMP-Activated Protein KinaseDevelopmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase Deficient MiceSystem Analysis of Cardiac Energetics -Excitation-Contraction CouplingPrinciples of Mathematical Modeling and In Silico Studies of Integrated Systems of Cellular EnergeticsModeling Energetics of Ion Transport, Membrane Sensing and System Biology of the HeartAPPLIED MOLECULAR SYSTEM BIOENERGETICSMitochondrial Adaptation to Exercise and Training -A Physiological ApproachMitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell PathophysiologyTumour Cell Energetic MetabolomeAMPK and the Metabolic SyndromeA Systems Biology Perspective of Obesity and Type 2 Diabetes