Chemical Biology

Herbert Waldmann obtained his PhD in organic chemistry from the University of Mainz in 1985 working with Professor Horst Kunz, after which he completed a postdoctoral appointment with Professor G. Whitesides at Harvard University. He was appointed as Professor of Organic Chemistry at the University of Bonn (1991), full Professor of Organic Chemistry at the University of Karlsruhe (1993), and Director at the MPI of Molecular Physiology Dortmund and Professor of Organic Chemistry at the University of Dortmund (1999). His research interests lie in the synthesis and use of small molecules in chemical biology research, the chemical biology of protein lipidation and protein microarrays. Petra Janning studied chemistry at the University of Munster, Germany, and did her PhD thesis at the Institute for Analytical Sciences in Dortmund (1995). After different positions where she worked in the area of analytical chemistry and on the borderline between chemistry and biology she joined the Max Planck Institute of Molecular Physiology, Dortmund, in the department of Professor H. Waldmann, where she is currently working. She is responsible for the bioorganic Practical Course and the analytics in the department. Her work is focused on the development of chromatographic and mass spectrometric methods used in the institute.

"This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to solve problems in biology by using techniques and tools taken from chemistry."METALL (1/2 2010)

• YEAST-BASED CHEMICAL GENOMIC APPROACHESIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/Evaluation -Chemogenomic Profiling: Elucidating the Mode of Action of Small MoleculesMIRCOARRAY-BASED STRATEGIES TO IDENTIFY UNKNOWN PROTEIN INTERACTIONSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationCOMPOUND COLLECTION SYNTHESIS FOR CHEMICAL BIOLOGYIntroductionChemical Probes -A Chemical Question with Biological ConsequencesDiversity Oriented Synthesis (DOS)Biology Oriented Synthesis (BIOS)TARGET IDENTIFICATION AND VALIDATION OF A WNT/BETA-CATENIN PATHWAY MODULATORIntroductionIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationACTIVITY-BASED PROTEIN PROFILING OF CYS PROTEASESIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationTHE USE OF PHOTOAFFINITY LABELING FOR THE IDENTIFICATION OF THE BINDING SITE OF THE ANTIBIOTIC LINEZOLIDIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationSURGICAL STRIKES: USES OF ANALOG SENSITIVE TECHNOLOGIES TO TARGET KINASES OF INTERESTIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/Evaluation: ASKA Technology -Applications in Molecular BiologyMODULATION OF PROTEIN-PROTEIN INTERACTIONS BY SMALL MOLECULESIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationTARGETED PROTEIN DEGRADATION IN LIVE CELLSIntroductionThe Biological ProblemThe Chemical ApproachTRAPOXIN B: FROM TOTAL SYNTHESIS TO EPIGENETICSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationNATIVE CHEMIAL LIGATION -A TOOL FOR CHEMICAL PROTEIN SYNTHESISIntroductionThe Synthetic ChallengeThe Chemical Approach -Native Chemical LigationChemical Biological Research/Evaluation -The Ras-RBD SystemsUSING SPLIT INTEINS TO PREPARE SEMI-SYNTHETIC PROTEINS AND TO STUDY THE MECHANISMS OF PROTEIN TRANS-SPLICINGIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationELUCIDATION OF THE RAS CYCLE WITH SEMI-SYNTHETIC PROTEINSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationTHE STUDY OF RAB GTPASE RECYCLING USING SEMI-SYNTHETIC PRENYLATED PROTEINSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationDEVELOPMENT OF A MODEL CANCER VACCINE CANDIDATE BASED ON THE MUCl CELLULAR SURFACE GLYCOPEPTIDE EPITOPEIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationTHE INTRODUCTION OF CHEMICAL REPORTER GROUPS BY BIOORTHOGONAL LIGATION REACTIONS FOR THE IMAGING OF CELL-SURFACE GLYCANSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationSEQUENCE SPECIFIC DNA-BINDING SMALL MOLECULES FOR PROTEIN RECRUITMENT AND MODULATION OF TRANSCRIPTIONIntroductionThe Biological Problem -Targeting DNA with Small MoleculesThe Chemical Approach: The Polyamide RationaleChemical Biological Research/Evaluation -Polyamides in Biological ApplicationsG-QUADRUPLEX LIGANDS AS TOOLS FOR ELUCIDATING C-MYC TRANSCRIPTIONAL REGULATIONIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/Evaluation