Atherosclerosis

Sarah George is a Reader in the Bristol Heart Institute at the University of Bristol. After obtaining her undergraduate and post-doctoral degree at the University of Cardiff she moved to the University of Bristol. Her research interests are the regulation of smooth muscle cell behaviour in atherosclerosis and restenosis, most recent studies have focused on the role of cell-cell contacts and the Wnt pathway. Dr George has written over 50 scientific original articles and was awarded the British Atherosclerosis Society John French Lecture in 2005. Jason Johnson is a British Heart Foundation Intermediate Research Fellow at the University of Bristol. He undertook both his Masters and Doctorate at the University of Bristol in the Bristol Heart Institute. His research interests are the role of matrix metalloproteinases in atherosclerosis and restenosis. He also contributed to the establishment of the first spontaneous mouse model of atherosclerotic plaque rupture. Dr Johnson was awarded the British Atherosclerosis Society Young Investigator Award

"This book [is] especially interesting for researchers in the pharmaceutical industry...also for those with more experience which will benefit from the summary of the last findings in the field." (RoSearch, December 2010)

• INTRODUCTIONPATHOGENESIS OF ATHEROSCLEROSIS. Sarah George & Cressida Lyon PROINFLAMMATORY FACTORSCHEMOKINES AND ATHEROSCLEROSIS: A CRITICAL ASSESSMENT OF THERAPEUTIC TARGETS. Gemma White, Keith Channon & David GreavesADHESION MOLECULES AND ATHEROSCLEROSIS Huan Wang & Yuqing HuoCYTOKINES AND ATHEROSCLEROSIS. Alain Tedgui, Hafid Ait-Oufella and Ziad MallatTOLL-LIKE RECEPTORS IN ATHEROSCLEROSIS Zhong-qun Yan, Kristina Edfeldt & Anna LundbergPPAR-BASED THERAPIES FOR THE MANAGEMENT OF ATHEROSCLEROSIS Florence Gizard & Ines Pineda-TorraPENTRAXINS IN VASCULAR PATHOLOGY: THE ROLE OF PTX3. Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi, Fabiola Molla & Roberto LatiniPROTEASESMETALLOPROTEINASES, THE ENDOTHELIUM AND ATHEROSCLEROSIS Stephen White & Andrew NewbyCATHEPSINS IN ATHEROSCLEROSIS Lili Bai, Esther Lutgens & Sylvia HeenemanTHE PLASMIN SYSTEM AND ATHEROSCLEROSIS Chris Jackson & Kevin CarsonMAST CELL PROTEASES AND ATHEROSCLEROSIS Petri KovanenHYPERLIPIDEMIAMACROPHAGE FOAM CELL FORMATION: THE PATHWAYS TO CHOLESTEROL ENGORGEMENT. Kathryn Moore & Katey RaynerOXIDATIVE STRESSNADPH OXIDASE AND ATHEROSCLEROSIS Jamie Jeremy, Saima Muzaffar, Carina Mill & Nilima ShuklaUNCOUPLING OF ENDOTHELIAL NITRIC OXIDE SYNTHASE IN ATHEROSCLEROSIS. Colin Cunnington & Keith ChannonHEME OXYGENASE-1 AND ATHEROSCLEROSIS Justin Mason & Faisal AliCELL GROWTH AND PHENOTYPEPHENOTYPIC HETEROGENEITY OF SMOOTH MUSCLE CELLS. IMPLICATIONS FOR ATHEROSCLEROSIS Marie-Matteo Coen and Luce Bochaton-PiallatPLATELETS: THEIR ROLE IN ATHEROGENESIS AND THROMBOSIS IN CORONARY ARTERY DISEASE. Matthew Harper, Lucy MacCarthy-Morrogh, Matthew Jones, Olga Konopatskaya & Alastair PooleMODULATORS OF MONOCYTE AND MACROPHAGE PHENOTYPES IN ATHEROSCLEROSIS Nick Jenkins & Jason Johnson