Unified polarization imaging theory for preclinical disease detection and diagnostics Detecting pathological tissue changes before clinical symptoms emerge requires imaging methods with high structural sensitivity. Polarization-Based Optical Imaging for Clinical Diagnostics presents a unified phenomenological theory integrating polarization interferometry, Mueller and Jones matrix mapping, digital holography, and phase scanning. Edited by a team of optical physicists with collectively over 1,000 Scopus-indexed publications, this reference establishes a coherent framework for 3D Jones-Mueller digital holographic mapping of biological tissues and fluids. The book details physical principles, experimental optical systems, and data analysis algorithms combining statistical, fractal, and wavelet approaches to differentiate pathological states with precision. Clinical applications span oncology, cardiology, gynecology, and forensic medicine, each demonstrated through concrete diagnostic scenarios. Software tools and image libraries accompany the methodology, enabling direct implementation of polarization-based diagnostic protocols in laboratory and clinical settings. Readers will also find: A unified phenomenological framework connecting polarization interferometry, Mueller matrix mapping, Jones matrix mapping, digital holography, and phase scanning techniquesDetailed algorithms for statistical, fractal, and wavelet analysis applied to optical mapping data from biological tissues and fluidsClinical diagnostic applications in oncology, cardiology, gynecology, and forensic medicine with pathological state differentiation methodsSoftware tools and image libraries supporting direct implementation of 3D Jones-Mueller digital holographic mapping protocolsExperimental system designs for polarization-based optical mapping enabling non-invasive preclinical detection of cancer, diabetes, and cardiovascular conditionsPolarization-Based Optical Imaging for Clinical Diagnostics serves biophysicists, clinical physicists, radiologists, and biomedical engineers seeking a rigorous, application-ready reference for polarization-based tissue characterization. By unifying theory, experimental methodology, and clinical validation in a single volume, it equips researchers and practitioners to advance non-invasive preclinical diagnostics.
