Acute Promyelitic Leukemia

Molecular Genetics, Mouse Models and Targeted Therapy

AvPier Paolo Pandolfi,Peter K. Vogt

Inbunden, Engelska, 2006

Del 313 i serien Current Topics in Microbiology and Immunology

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Beskrivning

Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.

Produktinformation

Utgivningsdatum:2006-12-13
Mått:155 x 235 x 23 mm
Vikt:653 g
Format:Inbunden
Språk:Engelska
Serie:Current Topics in Microbiology and Immunology
Antal sidor:274
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783540345923

Utforska kategorier

Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Medicinsk genetik inom Medicin

Innehållsförteckning

APL as a Paradigm in Biomedical Research: A Journey Toward the Cure.- Mouse Models of Acute Promyelocytic Leukemia.- The PLZF Gene of t(11;17)-Associated APL.- SUMO, the Three Rs and Cancer.- Emerging Role for MicroRNAs in Acute Promyelocytic Leukemia.- The Theory of APL Revisited.- Treatment of Acute Promyelocytic Leukemia by Retinoids.- Arsenic Trioxide and Acute Promyelocytic Leukemia: Clinical and Biological.- Front Line Clinical Trials and Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia.- Histone Deacetylase Inhibitors in APL and Beyond.- Monoclonal Antibody Therapy of APL.- Targeting APL Fusion Proteins by Peptide Interference.- The Design of Selective and Non-selective Combination Therapy for Acute Promyelocytic Leukemia.