At the 19th Annual Conference on Parallel Computational Fluid Dynamics held in Antalya, Turkey, in May 2007, the most recent developments and implementations of large-scale and grid computing were presented.  This book, comprised of the invited and selected papers of this conference, details those advances, which are of particular interest to CFD and CFD-related communities.  It also offers the results related to applications of various scientific and engineering problems involving flows and flow-related topics.  Intended for CFD researchers and graduate students, this book is a state-of-the-art presentation of the relevant methodology and implementation techniques of large-scale computing.