Botulinum Neurotoxins

Inbunden, Engelska, 2012

Del i serien Current Topics in Microbiology and Immunology

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Beskrivning

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Produktinformation

Utgivningsdatum:2012-12-14
Mått:155 x 235 x 23 mm
Vikt:630 g
Format:Inbunden
Språk:Engelska
Serie:Current Topics in Microbiology and Immunology
Antal sidor:324
Upplaga:2013
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783642335693

Utforska kategorier

Farmakologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

Genetic Diversity Within Clostridium botulinum Serotypes, Botulinum Neurotoxin Gene Clusters and Toxin Subtypes.- Assembly and Function of the Botulinum Neurotoxin Progenitor Complex.- Uptake of Botulinum Neurotoxin in the Intestine.- Double Receptor Anchorage of Botulinum Neurotoxins Accounts for their Exquisite Neurospecificity.- The Elusive Compass of Clostridial Neurotoxins: Deciding When and Where to Go?.- Synchronized Chaperone Function of Botulinum Neurotoxin Domains Mediates Light Chain Translocation into Neurons.- Clostridial Neurotoxin Light Chains: Devices for SNARE Cleavage Mediated Blockade of Neurotransmission.- Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins.- Persistence of Botulinum Neurotoxin Inactivation of Nerve Function.- Structure-Based Drug Discovery for Botulinum Neurotoxins.- Complexity of Botulinum Neurotoxins: Challenges for Detection Technology.- Progress in Cell Based Assays for Botulinum Neurotoxin Detection.- Transforming the Domain Structure of Botulinum Neurotoxins into Novel Therapeutics.- Botulinum Toxin: Application, Safety, and Limitations.