1 Concept of Genome Scanning.- 2 Principle of RLGS.- 3 Protocols for RLGS Gel Production.- 4 RLGS Spot Cloning.- 5 RLGS Spot Mapping Method.- 6 Application of RLGS to Screening Endogeneously Imprinted Genes.- 7 Systematic Detection of DNA Alteration in Cancer Tissue.- 8 RLCS, Restriction Landmark cDNA Scanning.- 9 Concluding Remarks.- Acknowledgments.- Abbreviations.- List of Suppliers.