Kathrin Herrmann is a veterinarian and expert for animal welfare science, ethics and law with focus on the 3Rs of animal experimentation. She currently works for the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University, MD, USA.Kimberley Jayne, PhD, has over a decade of research and educator experience working to enhance the welfare of animals in laboratory and entertainment environments. She now works in animal protection, using her experience to end the use of animals in these industries.

• ForewordPeter SingerPrefaceKathrin Herrmann and Kimberley JayneAcknowledgementNotes on ContributorsIntroductionKathrin Herrmann and Kimberley JaynePart 1: Why and How to Shift the Paradigm1 Refinement on the Way Towards Replacement: Are We Doing What We Can?Kathrin Herrmann2 How to Evaluate the Science of Non-human Animal Use in Biomedical Research and Testing: A Proposed Format for DebateRay Greek and Lisa A. Kramer3 How Can the Final Goal of Completely Replacing Animal Procedures Successfully be Achieved?Christiane Baumgartl-Simons and Christiane Hohensee4 Disease Prevention with a Plant-based LifestyleSabina VyasPart 2: Politics and Legislation of Animal Experimentation5 Political Campaigning: Where Scientific and Ethical Arguments Meet Public PolicyEmily McIvor6 Rethinking the 3Rs: From Whitewashing to RightsCharlotte E. Blattner7 Contesting Animal Experiments through Ethics and Epistemology: In Defense of a Political Critique of Animal ExperimentationArianna FerrariPart 3: Openness in Animal Experimentation8 The Moral Status of Animal Research Subjects in Industry: A Stakeholder AnalysisSarah Kenehan9 Increasing the Transparency of Animal Experimentation: An Australian PerspectiveMonika Merkes and Rob Buttrose10 Wasted Money in United States Biomedical and Agricultural Animal ResearchJim KeenPart 4: The Ethics and Philosophy of Animal Experimentation11 Ethics, Efficacy, and Decision-making in Animal ResearchLawrence A. Hansen and Kori Ann Kosberg12 Beyond Plausibility Checks: A Case for Moral Doubt in Review Processes of Animal ExperimentationMara-Daria Cojocaru and Philipp von Gall13 Human Wrongs in Animal Research: A Focus on Moral Injury and ReificationJane Johnson and Anna SmajdorPart 5: Effectiveness of the Animal Model14 Critically Evaluating Animal ResearchAndrew Knight15 Extrapolation of Animal Research Data to Humans: An Analysis of the EvidenceRebecca Ram16 Is Animal-based Biomedical Research being Used in Its Original Context?Constança Carvalho, Daniel Alves, Andrew Knight and Luis Vicente17 The Scientific Problems with Using Non-human Animals to Predict Human Response to Drugs and DiseaseRay Greek and Lisa A. Kramer18 Replacing Animal Tests to Improve Safety for HumansKathy Archibald, Robert Coleman and Tamara Drake19 Genetic Modification of Animals: Scientific and Ethical IssuesJarrod Bailey20 Animal Research for Alzheimer Disease: Failures of Science and EthicsJohn J. Pippin, Sarah E. Cavanaugh and Francesca Pistollato21 Behavioral Research on Captive Animals: Scientific and Ethical ConcernsKimberley Jayne and Adam SeePart 6: Animal-free Education and Training22 Modernizing Biomedical Training: Replacing Live Animal Laboratories with Human SimulationJohn Pawlowski, David Feinstein, Marie L. Crandall and Shalin Gala23 Humane Education: The Tool for Scientific Revolution in BrazilVanessa Carli Bones, Rita de Cassia Maria Garcia, Gutemberg Gomes Alves, Rita Leal Paixão, Alexandro Aluísio Rocha, Karynn Capilé and Róber BachinskiPart 7: The Paradigm Shift: Advanced Animal-free Approaches24 Recent Developments in Alternatives to Animal TestingKaty Taylor25 The Changing Paradigm in Preclinical Toxicology: in vitro and in silico Methods in Liver Toxicity EvaluationsFozia Noor26 The Potential of Organ on Chip Technology for Replacing Animal TestingMalcolm Wilkinson27 When is an Alternative Not an Alternative? Supporting Progress for Absolute Replacement of Animals in ScienceCraig Redmond28 Research and Testing Without Animals: Where are We Now and Where are We Heading?Thomas HartungAfterword: Evidence Over InterestsJohn P. GluckIndex

Kathrin Herrmann is a veterinarian and expert for animal welfare science, ethics and law with focus on the 3Rs of animal experimentation. She currently works for the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University, MD, USA.Kimberley Jayne, PhD, has over a decade of research and educator experience working to enhance the welfare of animals in laboratory and entertainment environments. She now works in animal protection, using her experience to end the use of animals in these industries.

• ForewordPeter SingerPrefaceKathrin Herrmann and Kimberley JayneAcknowledgementNotes on ContributorsIntroductionKathrin Herrmann and Kimberley JaynePart 1: Why and How to Shift the Paradigm1 Refinement on the Way Towards Replacement: Are We Doing What We Can?Kathrin Herrmann2 How to Evaluate the Science of Non-human Animal Use in Biomedical Research and Testing: A Proposed Format for DebateRay Greek and Lisa A. Kramer3 How Can the Final Goal of Completely Replacing Animal Procedures Successfully be Achieved?Christiane Baumgartl-Simons and Christiane Hohensee4 Disease Prevention with a Plant-based LifestyleSabina VyasPart 2: Politics and Legislation of Animal Experimentation5 Political Campaigning: Where Scientific and Ethical Arguments Meet Public PolicyEmily McIvor6 Rethinking the 3Rs: From Whitewashing to RightsCharlotte E. Blattner7 Contesting Animal Experiments through Ethics and Epistemology: In Defense of a Political Critique of Animal ExperimentationArianna FerrariPart 3: Openness in Animal Experimentation8 The Moral Status of Animal Research Subjects in Industry: A Stakeholder AnalysisSarah Kenehan9 Increasing the Transparency of Animal Experimentation: An Australian PerspectiveMonika Merkes and Rob Buttrose10 Wasted Money in United States Biomedical and Agricultural Animal ResearchJim KeenPart 4: The Ethics and Philosophy of Animal Experimentation11 Ethics, Efficacy, and Decision-making in Animal ResearchLawrence A. Hansen and Kori Ann Kosberg12 Beyond Plausibility Checks: A Case for Moral Doubt in Review Processes of Animal ExperimentationMara-Daria Cojocaru and Philipp von Gall13 Human Wrongs in Animal Research: A Focus on Moral Injury and ReificationJane Johnson and Anna SmajdorPart 5: Effectiveness of the Animal Model14 Critically Evaluating Animal ResearchAndrew Knight15 Extrapolation of Animal Research Data to Humans: An Analysis of the EvidenceRebecca Ram16 Is Animal-based Biomedical Research being Used in Its Original Context?Constança Carvalho, Daniel Alves, Andrew Knight and Luis Vicente17 The Scientific Problems with Using Non-human Animals to Predict Human Response to Drugs and DiseaseRay Greek and Lisa A. Kramer18 Replacing Animal Tests to Improve Safety for HumansKathy Archibald, Robert Coleman and Tamara Drake19 Genetic Modification of Animals: Scientific and Ethical IssuesJarrod Bailey20 Animal Research for Alzheimer Disease: Failures of Science and EthicsJohn J. Pippin, Sarah E. Cavanaugh and Francesca Pistollato21 Behavioral Research on Captive Animals: Scientific and Ethical ConcernsKimberley Jayne and Adam SeePart 6: Animal-free Education and Training22 Modernizing Biomedical Training: Replacing Live Animal Laboratories with Human SimulationJohn Pawlowski, David Feinstein, Marie L. Crandall and Shalin Gala23 Humane Education: The Tool for Scientific Revolution in BrazilVanessa Carli Bones, Rita de Cassia Maria Garcia, Gutemberg Gomes Alves, Rita Leal Paixão, Alexandro Aluísio Rocha, Karynn Capilé and Róber BachinskiPart 7: The Paradigm Shift: Advanced Animal-free Approaches24 Recent Developments in Alternatives to Animal TestingKaty Taylor25 The Changing Paradigm in Preclinical Toxicology: in vitro and in silico Methods in Liver Toxicity EvaluationsFozia Noor26 The Potential of Organ on Chip Technology for Replacing Animal TestingMalcolm Wilkinson27 When is an Alternative Not an Alternative? Supporting Progress for Absolute Replacement of Animals in ScienceCraig Redmond28 Research and Testing Without Animals: Where are We Now and Where are We Heading?Thomas HartungAfterword: Evidence Over InterestsJohn P. GluckIndex

Kathrin Herrmann is a veterinarian and expert for animal welfare science, ethics and law with focus on the 3Rs of animal experimentation. She currently works for the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University, MD, USA.Kimberley Jayne, PhD, has over a decade of research and educator experience working to enhance the welfare of animals in laboratory and entertainment environments. She now works in animal protection, using her experience to end the use of animals in these industries.

• ForewordPeter SingerPrefaceKathrin Herrmann and Kimberley JayneAcknowledgementNotes on ContributorsIntroductionKathrin Herrmann and Kimberley JaynePart 1: Why and How to Shift the Paradigm1 Refinement on the Way Towards Replacement: Are We Doing What We Can?Kathrin Herrmann2 How to Evaluate the Science of Non-human Animal Use in Biomedical Research and Testing: A Proposed Format for DebateRay Greek and Lisa A. Kramer3 How Can the Final Goal of Completely Replacing Animal Procedures Successfully be Achieved?Christiane Baumgartl-Simons and Christiane Hohensee4 Disease Prevention with a Plant-based LifestyleSabina VyasPart 2: Politics and Legislation of Animal Experimentation5 Political Campaigning: Where Scientific and Ethical Arguments Meet Public PolicyEmily McIvor6 Rethinking the 3Rs: From Whitewashing to RightsCharlotte E. Blattner7 Contesting Animal Experiments through Ethics and Epistemology: In Defense of a Political Critique of Animal ExperimentationArianna FerrariPart 3: Openness in Animal Experimentation8 The Moral Status of Animal Research Subjects in Industry: A Stakeholder AnalysisSarah Kenehan9 Increasing the Transparency of Animal Experimentation: An Australian PerspectiveMonika Merkes and Rob Buttrose10 Wasted Money in United States Biomedical and Agricultural Animal ResearchJim KeenPart 4: The Ethics and Philosophy of Animal Experimentation11 Ethics, Efficacy, and Decision-making in Animal ResearchLawrence A. Hansen and Kori Ann Kosberg12 Beyond Plausibility Checks: A Case for Moral Doubt in Review Processes of Animal ExperimentationMara-Daria Cojocaru and Philipp von Gall13 Human Wrongs in Animal Research: A Focus on Moral Injury and ReificationJane Johnson and Anna SmajdorPart 5: Effectiveness of the Animal Model14 Critically Evaluating Animal ResearchAndrew Knight15 Extrapolation of Animal Research Data to Humans: An Analysis of the EvidenceRebecca Ram16 Is Animal-based Biomedical Research being Used in Its Original Context?Constança Carvalho, Daniel Alves, Andrew Knight and Luis Vicente17 The Scientific Problems with Using Non-human Animals to Predict Human Response to Drugs and DiseaseRay Greek and Lisa A. Kramer18 Replacing Animal Tests to Improve Safety for HumansKathy Archibald, Robert Coleman and Tamara Drake19 Genetic Modification of Animals: Scientific and Ethical IssuesJarrod Bailey20 Animal Research for Alzheimer Disease: Failures of Science and EthicsJohn J. Pippin, Sarah E. Cavanaugh and Francesca Pistollato21 Behavioral Research on Captive Animals: Scientific and Ethical ConcernsKimberley Jayne and Adam SeePart 6: Animal-free Education and Training22 Modernizing Biomedical Training: Replacing Live Animal Laboratories with Human SimulationJohn Pawlowski, David Feinstein, Marie L. Crandall and Shalin Gala23 Humane Education: The Tool for Scientific Revolution in BrazilVanessa Carli Bones, Rita de Cassia Maria Garcia, Gutemberg Gomes Alves, Rita Leal Paixão, Alexandro Aluísio Rocha, Karynn Capilé and Róber BachinskiPart 7: The Paradigm Shift: Advanced Animal-free Approaches24 Recent Developments in Alternatives to Animal TestingKaty Taylor25 The Changing Paradigm in Preclinical Toxicology: in vitro and in silico Methods in Liver Toxicity EvaluationsFozia Noor26 The Potential of Organ on Chip Technology for Replacing Animal TestingMalcolm Wilkinson27 When is an Alternative Not an Alternative? Supporting Progress for Absolute Replacement of Animals in ScienceCraig Redmond28 Research and Testing Without Animals: Where are We Now and Where are We Heading?Thomas HartungAfterword: Evidence Over InterestsJohn P. GluckIndex