What type of exchanges occurred between West and East Asia in the first millennium CE? What sort of connections existed between Persia and China? What did the Chinese know of early Islam? This study offers an overview of the cultural, diplomatic, commercial, and religious relationships that flourished between Iran and China, building on the pioneering work of Berthold Laufer’s Sino-Iranica (1919) while utilizing a diverse array of Classical Chinese sources to tell the story of Sino-Iran in a fresh light to highlight the significance of transcultural networks across Asia in late antiquity.