MRI Contrast Agents

Dr. Sophie Laurent was born in 1967. Her studies were performed at the University of Mons-Hainaut (Belgium) where she received her PhD in Chemistry in 1993. She joined then Prof R.N. Muller’s team and was involved in the development (synthesis and physicochemical characterization) of paramagnetic Gd complexes and superparamagnetic iron oxide nanoparticles as contrast agents for MRI. She is currently working on the vectorization of contrast agents for molecular imaging. She is associate professor and co-author around 170 publications and more than 250 communications in international meetings.Dr. Dimitri Stanicki did his graduate work at the University of Mons (Ph.D. degree in 2010), where he achieved the synthesis of organic compounds for the treatment of parasitic diseases. In 2011, he joined R. Muller’s research group (MRI) where he started to develop new nanosystems for molecular imaging applications. He is the co-author of approximatively 10 publications, including a patentand a chapter book in the field of superparamagnetic contrast agents.Dr. Robert N. Muller, PhD in chemistry 1974 from the University of Mons-Hainaut where he was successively appointed Assistant, Lecturer and full Professor. Post-doctoral studies in Magnetic Resonance Imaging in Paul C. Lauterbur’s (2003 Nobel Prize in Medicine or Physiology) research group (MRI) at the State University of New York at Stony Brook in 1981-82 and sabbatical leave at the Center for Magnetic Resonance (CERM), Florence, Italy, in 2002-2003. He produced around 280 publications and 6 books. Currently Scientific Director of the Center for Microscopy and Molecular Imaging, Gosselies, Belgium.

• Nanomaterials in medicine.- Magnetic properties (diamagnetism, paramagnetism, ferromagnetism, ferrimagnetism, antiferromagnetism, superparamagnetism).- Imaging probes.- Magnetic resonance imaging (MRI).- Bases of MRI.- MRI contrast agents.- Paramagnetic gadolinium complexes.- Superparamagnetic iron oxide nanoparticles.- Synthesis of magnetic nanoparticles.- Stabilization of magnetic nanoparticles.- Physico-chemical characterization of nanoparticles.- MRI applications.- Conclusions.