Reiko KishiCenter for Environmental and Health SciencesHokkaido UniversitySapporoHokkaido, Japan Philippe GrandjeanHarvard T.H. Chan School of Public HealthDepartment of Environmental HealthBostonMassachusetts, USA University of Southern DenmarkDepartment of Environmental MedicineDenmark

• Part 1 Introduction.- 1 Impacts of developmental exposure to environmental chemicals on human health with global perspectives.- Part 2 Adverse health effects on human developing organs caused by environmental chemicals-the role that chemicals might play.- 2 Environmental exposures and adverse pregnancy-related outcomes.- 3 Effects of Environmental Chemical Exposure on Birth Defects (Except Cryptorchidism and Hypospadias).- 4 Cryptorchidism and hypospadias.- 5     Endocrine-distributing chemicals and reproductive function.- 6 Thyroid hormone system and development.- 7 Neurodevelopment and Neurobehavioral disorders in relation to developmental exposures.- 8 Immunotoxicity: Impacts and research approaches.- 9 Long-Term Implications of Developmental Programming and Obesity.- Part 3 Impact of Environmental Chemical Hazards on human development.- 10 Impact of Air Pollution Hazards on Human Development.- 11 Mercury, Lead, Manganese and Hazardous Metals.- 12 Environmental Pollution and Recent Data on Asian Children’s Health in Relation to Pre- and Early Post-natal Exposure to Persistent Organic Pollutants, Including PCBs, PCDD/PCDFs, and Organochlorine Pesticides.- 13 Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring.- 14 Brominated flame retardants (BFRs).- 15 Exposure to phthalate acid esters and the its health effects.- 16 Bisphenols and alkylphenols.- Part 4 Important aspects of research for prevention and strategy.- 17 Adverse Outcome Pathways for Developmental Toxicity.- 18 Exposomics-The Exposome in Early Life.- 19 Gene-Environment Interactions to Detect Adverse Health Effects on the Next Generation.- 20 Epigenetics – Strategies for Prevention Research.- 21 From research to intervention.- Part 5 Closing.- 22 Further direction of research  and policy making of environment and children's health.

Reiko KishiCenter for Environmental and Health SciencesHokkaido UniversitySapporoHokkaido, Japan Philippe GrandjeanHarvard T.H. Chan School of Public HealthDepartment of Environmental HealthBostonMassachusetts, USA University of Southern DenmarkDepartment of Environmental MedicineDenmark

• Part 1 Introduction.- 1 Impacts of developmental exposure to environmental chemicals on human health with global perspectives.- Part 2 Adverse health effects on human developing organs caused by environmental chemicals-the role that chemicals might play.- 2 Environmental exposures and adverse pregnancy-related outcomes.- 3 Effects of Environmental Chemical Exposure on Birth Defects (Except Cryptorchidism and Hypospadias).- 4 Cryptorchidism and hypospadias.- 5     Endocrine-distributing chemicals and reproductive function.- 6 Thyroid hormone system and development.- 7 Neurodevelopment and Neurobehavioral disorders in relation to developmental exposures.- 8 Immunotoxicity: Impacts and research approaches.- 9 Long-Term Implications of Developmental Programming and Obesity.- Part 3 Impact of Environmental Chemical Hazards on human development.- 10 Impact of Air Pollution Hazards on Human Development.- 11 Mercury, Lead, Manganese and Hazardous Metals.- 12 Environmental Pollution and Recent Data on Asian Children’s Health in Relation to Pre- and Early Post-natal Exposure to Persistent Organic Pollutants, Including PCBs, PCDD/PCDFs, and Organochlorine Pesticides.- 13 Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring.- 14 Brominated flame retardants (BFRs).- 15 Exposure to phthalate acid esters and the its health effects.- 16 Bisphenols and alkylphenols.- Part 4 Important aspects of research for prevention and strategy.- 17 Adverse Outcome Pathways for Developmental Toxicity.- 18 Exposomics-The Exposome in Early Life.- 19 Gene-Environment Interactions to Detect Adverse Health Effects on the Next Generation.- 20 Epigenetics – Strategies for Prevention Research.- 21 From research to intervention.- Part 5 Closing.- 22 Further direction of research  and policy making of environment and children's health.

Reiko KishiCenter for Environmental and Health SciencesHokkaido UniversitySapporoHokkaido, Japan Philippe GrandjeanHarvard T.H. Chan School of Public HealthDepartment of Environmental HealthBostonMassachusetts, USA University of Southern DenmarkDepartment of Environmental MedicineDenmark

• Part 1 Introduction.- 1 Impacts of developmental exposure to environmental chemicals on human health with global perspectives.- Part 2 Adverse health effects on human developing organs caused by environmental chemicals-the role that chemicals might play.- 2 Environmental exposures and adverse pregnancy-related outcomes.- 3 Effects of Environmental Chemical Exposure on Birth Defects (Except Cryptorchidism and Hypospadias).- 4 Cryptorchidism and hypospadias.- 5     Endocrine-distributing chemicals and reproductive function.- 6 Thyroid hormone system and development.- 7 Neurodevelopment and Neurobehavioral disorders in relation to developmental exposures.- 8 Immunotoxicity: Impacts and research approaches.- 9 Long-Term Implications of Developmental Programming and Obesity.- Part 3 Impact of Environmental Chemical Hazards on human development.- 10 Impact of Air Pollution Hazards on Human Development.- 11 Mercury, Lead, Manganese and Hazardous Metals.- 12 Environmental Pollution and Recent Data on Asian Children’s Health in Relation to Pre- and Early Post-natal Exposure to Persistent Organic Pollutants, Including PCBs, PCDD/PCDFs, and Organochlorine Pesticides.- 13 Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring.- 14 Brominated flame retardants (BFRs).- 15 Exposure to phthalate acid esters and the its health effects.- 16 Bisphenols and alkylphenols.- Part 4 Important aspects of research for prevention and strategy.- 17 Adverse Outcome Pathways for Developmental Toxicity.- 18 Exposomics-The Exposome in Early Life.- 19 Gene-Environment Interactions to Detect Adverse Health Effects on the Next Generation.- 20 Epigenetics – Strategies for Prevention Research.- 21 From research to intervention.- Part 5 Closing.- 22 Further direction of research  and policy making of environment and children's health.