This book constitutes the proceedings of the 18th Chinese Intelligent Systems Conference, CISC 2022, which was held during October 15–16, 2022, in Beijing, China.The papers in these proceedings deal with various topics in the field of intelligent systems and control, such as multi-agent systems, complex networks, intelligent robots, complex system theory and swarm behavior, event-triggered control and data-driven control, robust and adaptive control, big data and brain science, process control, intelligent sensor and detection technology, deep learning and learning control guidance, navigation and control of aerial vehicles.