Therapy with Cultured Cells

Dr. Green received his Doctorate in Medicine at the University of Toronto. He began his independent scientific work at New York University School of Medicine, where he ultimately became Professor and Chairman of the Department of Cell Biology. From 1970-1980 he was Professor of Cell Biology at Massachusetts Institute of Technology. He came to Harvard Medical School in 1980 and served as Chairman of the Department of Cellular and Molecular Physiology from then until 1993. Since then he has been George Higginson Professor in the Department of Cell Biology. While at MIT and Harvard Medical School, he developed the first therapeutic use of cultured cells - the use of keratinocytes for the regeneration of epidermis on severely burned patients. The first large-scale, life-saving use of this procedure was demonstrated with cells grown in his laboratory on the 6th floor of Building C2, where his lab is still located.

"This book contains a personal account of the development of therapy with cultured cells by the founder of the field. He describes the first application which he developed for the treatment of burn patients. This methodology was then applied by others to the treatment of eye diseases and the restoration of vision after chemical burns. Later, other cultured cell types, such as cartilage cells, were introduced for human therapy. These applications are all current in many parts of the world. A must read for all cell biology students!"—Prof. Tung-Tien Sun, New York University Medical School, USA

• The Early History of Cell Culture. The Beginnings of Keratinocyte Cultivation. The Treatment of Burns. Defining the Stem Cell Character of Keratinocytes. Treatment with Allogeneic Cultured Keratinocytes. Treatment of Ocular Disease. Gene Therapy. Therapy with Cultured Chondrocytes. The Promise of Therapy with Embryonic Stem Cells.