This book explores the rapidly advancing intersection of biomaterials science and clinical diagnostics and therapeutics, collectively known as Theranostics. It focuses on the design, development, and translational application of extracellular matrix (ECM)–mimicking biomaterials as next-generation platforms for improving diagnostic accuracy, therapeutic delivery, and treatment predictability—particularly in cancer, tissue regeneration, and personalized medicine.At its core, the book examines how biomimetic ECM systems replicate the structural, biochemical, and mechanical cues of native tissues, enabling more physiologically relevant in vitro and in vivo environments. By emulating the dynamic and hierarchical architecture of the ECM, these materials demonstrate significant potential in enhancing drug delivery, predicting therapeutic efficacy, and facilitating tissue repair and regeneration.The book provides in-depth coverage of advanced fabrication strategies, including 3D bioprinting, molecular self-assembly, and decellularization-based approaches, for creating functional ECM analogs. Each chapter presents case studies, experimental findings, and applied methodologies, illustrating how ECM biomimicry is being integrated into theranostic systems across diverse biomedical applications. A distinguishing feature of this volume is its incorporation of high-quality illustrations, 3D renderings, and comprehensive tables, which visually elucidate complex mechanisms, material architectures, and data interpretation. This book offers a holistic framework for leveraging ECM biomimicking in Theranostics by bridging fundamental biomaterials research with applied clinical translation. It serves as a valuable resource for biomaterials scientists, bioengineers, clinicians, and translational researchers seeking to stay at the forefront of regenerative medicine, cancer therapy, and diagnostic innovation.
