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31 produkter
Häftad, Engelska, 2024
278 kr
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Inbunden, Engelska, 2025
376 kr
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This second volume on the LNER 4-4-0 locomotives describes the design, construction, history, operation and performance of the North Eastern, North British, Great North of Scotland and Gresley LNER built examples, classified by the LNER at the Grouping as classes, D17 - D24, D25 - D36, D38 - D48 and D49 respectively. It covers from their emergence in the late nineteenth century to their demise in the mid or late 1950s and early 1960s with their performance at their peak operation times, mainly in the inter-war years of LNER ownership.
Häftad, Engelska
269 kr
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Inbunden, Engelska, 2021
376 kr
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L N E R 4-6-0 Tender Mixed Traffic Locomotives covers the design, construction, operation and performance of all 4-6-0 locomotives that ran on the London & North Eastern Railway between 1923 and 1947 and the LNER designed engines that ran on BR's Eastern Region until the end of BR steam in 1968\. This includes the former Great Central 4-6-0s of classes B1 - B9 (the B1 and B2 later reclassified B18 & B19); the North Eastern Railway B13 - B16s; the Great Eastern B12s; and the LNER B17s, the Thompson B1s and rebuilds (B2 and B3/3). The book has over 60,000 words and 400 black and white and coloured photographs, many previously unpublished from the archives of the Manchester Locomotive Society at Stockport. It will be of particular interest to railway modellers and enthusiasts of locomotive running and performance as well as those seeking more general locomotive history. The book is designed and written in the same style as David Maidment's previous Locomotive Portfolio books on engines of the Great Western and Southern Railways, and includes where possible his own experiences, seeing and travelling behind engines of these classes in the 1950s and early 1960s, especially the B1s, B12s and B17 'Sandringhams'.
Inbunden, Engelska, 2018
3 063 kr
Skickas inom 10-15 vardagar
This book is Volume 2 of the EUROCK 2018 proceedings. Geomechanics and Geodynamics of Rock Masses contains contributions presented at EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22-26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the main topics of the book include:- Physical and mechanical properties of fractured rock (laboratory testing and rock properties, field measurements and site investigations)- Geophysics in rock mechanics- Rock mass strength and failure- Nonlinear problems in rock mechanics- Effect of joint water on the behavior of rock foundation- Numerical modeling and back analysis- Mineral resources development: methods and rock mechanics problems- Rock mechanics and underground construction in mining, hydropower industry and civil engineering- Rock mechanics in petroleum engineering- Geodynamics and monitoring of rock mass behavior- Risks and hazards- Geomechanics of technogenic depositsGeomechanics and Geodynamics of Rock Masses will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.
Inbunden, Engelska, 2018
8 325 kr
Skickas inom 5-8 vardagar
The International Committee on Large Dams (ICOLD) held its 26th International Congress in Vienna, Austria (1-7 July 2018). The proceedings of the congress focus on four main questions: 1. Reservoir sedimentation and sustainable development; 2. Safety and risk analysis; 3. Geology and dams, and 4. Small dams and levees. The book thoroughly discusses these questions and is indispensable for academics, engineers and professionals involved or interested in engineering, hydraulic engineering and related disciplines.
Inbunden, Engelska, 2016
2 772 kr
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Materials for Ultra-Supercritical and Advanced Ultra-Supercritical Power Plants provides researchers in academia and industry with an essential overview of the stronger high-temperature materials required for key process components, such as membrane wall tubes, high-pressure steam piping and headers, superheater tubes, forged rotors, cast components, and bolting and blading for steam turbines in USC power plants. Advanced materials for future advanced ultra-supercritical power plants, such as superalloys, new martensitic and austenitic steels, are also addressed. Chapters on international research directions complete the volume.
The transition from conventional subcritical to supercritical thermal power plants greatly increased power generation efficiency. Now the introductions of the ultra-supercritical (USC) and, in the near future, advanced ultra-supercritical (A-USC) designs are further efforts to reduce fossil fuel consumption in power plants and the associated carbon dioxide emissions. The higher operating temperatures and pressures found in these new plant types, however, necessitate the use of advanced materials.
Provides researchers in academia and industry with an authoritative and systematic overview of the stronger high-temperature materials required for both ultra-supercritical and advanced ultra-supercritical power plants Covers materials for critical components in ultra-supercritical power plants, such as boilers, rotors, and turbine blades Addresses advanced materials for future advanced ultra-supercritical power plants, such as superalloys, new martensitic and austenitic steels Includes chapters on technologies for welding technologies
Inbunden, Engelska, 2013
801 kr
Skickas inom 10-15 vardagar
Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.
Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.
For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development
Häftad, Engelska, 2021
188 kr
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Häftad, Engelska, 2021
201 kr
Skickas inom 5-8 vardagar
175 kr
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Inbunden, Engelska, 2023
335 kr
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Häftad, Engelska, 2024
729 kr
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Excavation, Support and Monitoring is the fourth volume of the five-volume set Rock Mechanics and Engineering and contains twenty-three chapters from key experts in the following fields- Excavation Methods;- Support Technology;- Monitoring Technology;- Integrated Engineering Monitoring and Analysis.The five-volume set “Comprehensive Rock Engineering”, which was published in 1993, has had an important influence on the development of rock mechanics and rock engineering. Significant and extensive advances and achievements in these fields over the last 20 years now justify the publishing of a comparable, new compilation. Rock Mechanics and Engineering represents a highly prestigious, multi-volume work edited by Professor Xia-Ting Feng, with the editorial advice of Professor John A. Hudson. This new compilation offers an extremely wide-ranging and comprehensive overview of the state-of-the-art in rock mechanics and rock engineering and is composed of peer-reviewed, dedicated contributions by all the key experts worldwide.Key features of this set are that it provides a systematic, global summary of new developments in rock mechanics and rock engineering practices as well as looking ahead to future developments in the fields. Contributors are world-renowned experts in the fields of rock mechanics and rock engineering, though younger, talented researchers have also been included. The individual volumes cover an extremely wide array of topics grouped under five overarching themes: Principles (Vol. 1), Laboratory and Field Testing (Vol. 2), Analysis, Modelling and Design (Vol. 3), Excavation, Support and Monitoring (Vol. 4) and Surface and Underground Projects (Vol. 5). This multi-volume work sets a new standard for rock mechanics and engineering compendia and will be the go-to resource for all engineering professionals and academics involved in rock mechanics and engineering for years to come.
Häftad, Engelska, 2017
1 605 kr
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Nanoelectronic Device Applications Handbook gives a comprehensive snapshot of the state of the art in nanodevices for nanoelectronics applications. Combining breadth and depth, the book includes 68 chapters on topics that range from nano-scaled complementary metal–oxide–semiconductor (CMOS) devices through recent developments in nano capacitors and AlGaAs/GaAs devices. The contributors are world-renowned experts from academia and industry from around the globe.The handbook explores current research into potentially disruptive technologies for a post-CMOS world. These include:Nanoscale advances in current MOSFET/CMOS technologyNano capacitors for applications such as electronics packaging and humidity sensorsSingle electron transistors and other electron tunneling devicesQuantum cellular automata and nanomagnetic logicMemristors as switching devices and for memoryGraphene preparation, properties, and devicesCarbon nanotubes (CNTs), both single CNT and random networkOther CNT applications such as terahertz, sensors, interconnects, and capacitorsNano system architectures for reliabilityNanowire device fabrication and applicationsNanowire transistorsNanodevices for spintronicsThe book closes with a call for a new generation of simulation tools to handle nanoscale mechanisms in realistic nanodevice geometries. This timely handbook offers a wealth of insights into the application of nanoelectronics. It is an invaluable reference and source of ideas for anyone working in the rapidly expanding field of nanoelectronics.
Inbunden, Engelska, 2015
2 647 kr
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This volume, originally published in 1975, grew out of Resources for the Future’s involvement as a consultant to the Marine Ecosystem Analysis programme management within the National Oceanic and Atmospheric Agency. Here, researchers look at the state of the art in aquatic ecological modelling in a resource management context. Although the aim of the research in this volume is specific, the models used can be applied in broader contexts and provide conceptual frameworks for regional residuals-environmental quality management and other ecological modelling. This title is suitable for students interested in Environmental Studies.
Häftad, Engelska, 2017
563 kr
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This volume, originally published in 1975, grew out of Resources for the Future’s involvement as a consultant to the Marine Ecosystem Analysis programme management within the National Oceanic and Atmospheric Agency. Here, researchers look at the state of the art in aquatic ecological modelling in a resource management context. Although the aim of the research in this volume is specific, the models used can be applied in broader contexts and provide conceptual frameworks for regional residuals-environmental quality management and other ecological modelling. This title is suitable for students interested in Environmental Studies.
Inbunden, Engelska, 2027
2 373 kr
Kommande
Inbunden, Engelska, 2024
376 kr
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This first volume on the LNER 4-4-0 locomotives describes the design, construction, history, operation and performance of the Great Northern, Great Central and Great Eastern examples, classified by the LNER at the Grouping as classes, D1 - D4, D5 - D12 and D13 - D16 respectively. It covers from their emergence in the late nineteenth century to their demise in the mid or late 1950s and their performance at their peak operation times, mainly in the inter-war years of LNER ownership. It also includes the former Midland & Great Northern Railway engines that were later absorbed by the LNER as classes D52 - D54.
Inbunden, Engelska, 2023
376 kr
Skickas
In their book Gresley's Silver Link' the authors analysed the evolution of the A4s Gresley's and their service up to Gresley's death in 1941\. This book takes this compelling story from the early years of the war up to their demise in the 1960sAfter four years of service pulling the LNER's most prestigious trains the A4s took on a more utilitarian role and for six years worked hard to support Britain's war effort. From this they emerged bowed, but unbeaten, although in an extremely jaded condition. Once restored they took up where they had left off in 1939 and did exceptional service for the rest of their days.With the help of previously unpublished material the authors analyse the second phase of the A4s careers, first as LNER engines, then, from 1948, under British Railways management. Without a diesel or electric fleet of engines to replace them they entered a second golden age of fast running in the 50s. Then in the Swinging Sixties' they faced, as some thought, a premature end as part of a much delayed modernisation programme. Until withdrawn from service they continued to astound their footplate crew and performed exceptionally well, even when maintenance standards had slipped and their condition had deteriorated. They were thoroughbreds and have become a fitting memorial to the master engineers who produced and sustained them for 30 years or more.
Häftad, Engelska, 2014
144 kr
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Häftad, Engelska, 2016
280 kr
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Inbunden, Engelska, 2016
459 kr
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Inbunden, Engelska, 2006
951 kr
Skickas inom 10-15 vardagar
The cholinergic system has been recognized as playing an important role not only in several forms of dementia besides Alzheimer's Disease, but also in other CNS degenerative and psychiatric disorders. Following on from the success of two previous publications in the cholinergic field - Cholinesterases and Their Inhibitors and Butyrylcholinesterase: Its Function and Inhibitors - Doctor Ezio Giacobini and Professor Giancarlo Pepeu have prepared this comprehensive and timely volume, which will be useful to both clinical and pre-clinical specialists including neurologists, psychiatrists, neuropsychologists, neuropharmacologists and neurophysiologists, molecular neurobiologists and neurobiologists in general.
Inbunden, Engelska, 2001
2 869 kr
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Molecular Genetics of Cancer, Second Edition provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. The book is therefore a valuable source of reference for clinicians and genetic counsellors as well as researchers.
Häftad, Franska, 2019
153 kr
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Inbunden, Engelska, 2022
554 kr
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This textbook provides details of the derivation of Lagrange's planetary equations and of the closely related Gauss's variational equations, thereby covering a sorely needed topic in existing literature.
Häftad, Engelska, 2023
400 kr
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This textbook provides details of the derivation of Lagrange's planetary equations and of the closely related Gauss's variational equations, thereby covering a sorely needed topic in existing literature.
Häftad, Tyska, 1991
577 kr
Skickas inom 10-15 vardagar
Die klinische Prüfung von Arzneimitteln vor der Zulassung hat einen hohen wissenschaftlichen Standard erreicht. Das vorliegende Buch macht deutlich, daß diese Forschungsphase aufgrund der zeitlichen Limitierung dennoch keine abschließenden Ergebnisse hinsichtlich Wirksamkeit und Sicherheit eines Arzneimittels liefern kann. Eine kontinuierliche begleitende Forschung auch nach der Zulassung eines Arzneimittels ist daher unabdingbar und liegt gleichermaßen im Interesse von Patienten, Ärzten und Arzneimittelherstellern. In umfassender und systematischer Weise wird die Vielfalt der Fragestellungen einer Arzneimittelforschung nach der Zulassung herausgearbeitet und deutlich gemacht, daß nur eine erhebliche Ausweitung des Methodenspektrums über die bekannten Methoden hinaus diesen Anforderungen gerecht werden kann. Das Buch bietet eine systematische Beschreibung der wichtigsten methodischen Instrumente, wobei besonders ausführlich die Studienform und Methoden der sog. Pharmakoepidemiologie behandelt werden, für die bisher keine Verfahrensrichtlinien und Qualitätsnormen existierten. Zahlreiche Wissenschaftler und Experten aus den Bereichen Biometrie, Pharmakologie und Innere Medizin haben zu diesem Buch beigetragen. Es ist die bisher einzige so umfassende und systematische Darstellung des Themas "Arzneimittelforschung nach der Zulassung" in der deutschsprachigen Fachliteratur. Die Realisierung des aufgezeigten Forschungsbedarfs nach der Zulassung eines Arzneimittels bei Arzneimittelherstellern, der Ärzteschaft, Behörden und Forschungseinrichtungen und der sachgerechte Einsatz des in diesem Buch beschriebenen Methodenrepertoires kann einen wesentlichen Beitrag zur Erhöhung der Arzneimittelsicherheit leisten.
Häftad, Engelska, 2011
1 083 kr
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Studies of the perception and transduction of hormonal signals in higher plants are relatively recent. Despite the rather small number of researchers involved in comparison, say, to those studying signalling in animals, plant scientists are becoming attracted to this important field because of the fascinating mechanisms being revealed and the recognition that any hope of understanding the ways in which the growth and development of the whole plant are controlled can only be based on an exploration of the physiology, biochemistry and molecular biology of these mechanisms. The Moscow symposium that gave rise to the present book drew many of the most active workers in the area, and many new developments were revealed. Audience: Important reading for all those interested in plant growth and development.
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