Aaron I. Vinik – författare

This two-part issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with comprehensive essential updates about tumors of the gastroenteropancreatic system. Topics covered include the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders; new and emerging syndromes related to gastrointestinal (GI) hormones; an update on incretins; prospects for ghrelin in the clinic, obesity/appetite and hedonism; GI motility disorders; gastric bypass and GI hormones; pancreatic exocrine function and GI hormones; harnessing the pancreatic stem cell; how to diagnose NETs before there are METs; NETs in kids: combining the SEER data for children and adults with site differences; novel biomarkers for NETs; standard imaging techniques for NETs; novel peptide imaging: glucagon receptor; signaling mechanism in NETs as targets for therapy; update on clinical trials; nutrition and the GEP; peptide radiotherapy; in vitro analysis of NETs: the role of angiogenesis; modern lab evaluation of peptide and amines: a continuing role for radioimmunoassay?; surgery/surgical management of NETs; and evaluation and quality of life in NETs patients.

Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.

Comprehensive and timely, Controversies in Treating Diabetes: Clinical and Research Aspects is an essential reference for those treating and researching diabetes.

Diabetes Mellitus is an extremely common disorder and the number of patients is increasing every year. Controversies in Treating Diabetes: Clinical and Research Aspects addresses diabetes controversies, specifically in the etiology and management of the disease. With a thorough examination of the complications associated with diabetes, the volume covers commonly accepted forms of therapies and complications, as well as new and emerging advances, therapies and inadequacies in several standard treatments. Topics of emphasis include the metabolic syndrome, using insulin to treat Type 2, retinopathy, neuropathy, environmental stress, the diabetic foot, incretins, and the ADA and NCEP criteria for treating hyperlipidemia of diabetes. Comprehensive and timely, Controversies in Treating Diabetes: Clinical and Research Aspects is an essential reference for those treating and researching diabetes.

This book presents the concepts underlying the measurement of parasympathetic and sympathetic (P&S) activity in the autonomic nervous system and the application of these measurements in the development of therapeutic guidelines for treating dysfunctions in these processes.