Nicholas L. DePace – författare

What causes chronic and persistent fatigue in so many people? How is it best prevented and treated? What can patients and physicians do to better understand this common medical issue? Fatigue is an extremely common component of many physical and mental disorders, from anxiety and depression to heart disease and hypertension. Many patients even find themselves suffering from persistent fatigue with little understanding of how to safely and effectively treat the issue, especially if their symptoms don’t qualify for diagnosis as Chronic Fatigue Syndrome, which can make them “fall through the cracks” of the medical system.  But now, with Fatigue and Dysautonomia: Chronic or Persistent, What’s the Difference?, physicians Joseph Colombo and Nicholas L. DePace aim to close those cracks, offering a simplified analysis and discussion focusing on this common patient complaint and how best to treat it. Topics covered include: ​ Parasympathetic and Sympathetic (P&S) causes of both chronic and “persistent” fatigue Natural therapies to help relieve fatigue and promote wellness.  Concepts of fatigue, the six-pronged Mind-Body Wellness Program, and the P&S nervous systems.  Causal relationships between fatigue and P&S dysfunction (a more specific description of autonomic dysfunction or dysautonomia) How to treat fatigue with supplements and lifestyle modifications that have been documented to work without the added side-effects of most pharmaceutical therapies.  Presenting discussions with patients and doctors side-by-side to help physicians see how to present information to their patients and patients to learn what physicians need to know to tailor therapy to their individual needs, Fatigue and Dysautonomia is an essential resource for anyone concerned with fatigue, from medical professionals to patients to family and friends.

This book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings. It includes lifestyle and supplement recommendations for beginning and maintaining autonomic nervous system and mitochondrial health and wellness. The book is organized around a six-pronged mind-body wellness program and contains a series of clinical applications and frequently asked questions. The physiologic need and clinical benefit and synergism of all six aspects working together are detailed, including the underlying biochemistry, with exhaustive references to statistically significant and clinically relevant studies. The book covers a range of clinical disorders, including anxiety, arrhythmia, atherosclerosis, bipolar disease, dementia, depression, fatigue, fibromyalgia, heart diseases, hypertension, mast cell disorder, migraine, and PTSD. Clinical Autonomic and Mitochondrial Disorders: Diagnosis, Prevention, and Treatment for Mind-Body Wellness is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, primary care, neurology, endocrinology, psychiatry, and integrative and functional medicine. It provides therapy options to the indications and diagnoses published in the authors' book Clinical Autonomic Dysfunction (Springer, 2014).

This book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings.

This book covers Ehlers-Danlos and hypermobility syndromes with an emphasis on treatment of the parasympathetic and sympathetic (P&S) nervous system dysfunctions. Unfortunately, most EDS/HSD patients have been misdiagnosed and misunderstood by providers.  EDS/HSD is a multisystem, multifaceted disorder that is poorly understood. The P&S manifestations and treatments are also poorly understood throughout the healthcare community.  To this end the authors wish to teach providers and patients alike to reduce the life-long suffering from both the disorder and the marginalization. There are two aspects of teaching that are required and provided by this book: improved understanding of EDS/HSD and improved understanding of P&S (autonomic) dysfunction and treatment.  For example, with the autonomic nervous system, more treatment or therapy is never better.  Relief of P&S dysfunction must be low and slow to prevent causing more symptoms from higher doses of medication or polypharmacy.  To this end, stress often sets patients back and both providers and patients alike must have proper expectations set for successfully improving patient outcomes (quality of life and productivity). The book starts with an introduction to and history of the disorder. Chapter II provides a review of the genetics of collagen, the source of the disorders.  Chapters III through IX detail the various forms of EDS/HSD and goes into more detail on the more common and more well-known variants of EDS/HSD. Chapter X discusses structural cardiovascular and pulmonary dysfunction associated with EDS/HSD.  Chapter XI discusses structural gastrointestinal and urogenital dysfunction associated with EDS/HSD.  The book ends with Chapter XII, which details the involvement of the P&S nervous systems and how to treat, which also has general application to other chronic disorders.This is an ideal guide for rheumatologists and primary care physicians treating patients with Ehlers-Danlos and hypermobility syndromes, and patients and their loved ones in understanding their disease and disorders and the associated treatments and therapies.

This book presents the concepts underlying the measurement of parasympathetic and sympathetic (P&S) activity in the autonomic nervous system and the application of these measurements in the development of therapeutic guidelines for treating dysfunctions in these processes.