Ahmed El-Hashash – författare

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology.

Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases.

Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world.

Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung

The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases.

Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world.

Provides intensive scientific background and most recent information on cutting edge research to understand intestinal stem cell functions and develop methods to bring stem cells from bench to bedside for different intestinal diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and the CRISPR gene editing system in the intestine Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the intestine

Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside. Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases. Provides cutting-edge research needed to understand stem cell functions in joint and bone diseases Develops processes to bring stem cells from bench to bedside Includes up-to-date references on stem cell biology and function in the joint and bone

Biomedical Basis of Human Disease: From Research to Clinic provides information on pathophysiology/mechanisms of organ system disease and selected disorders and diseases that cause the most deaths worldwide, including but not limited to cardiovascular, respiratory, gastrointestinal and nervous systems. This information is placed within the structural context of tissue/organ, molecular and cellular biology, pathophysiology, diagnostic and treatment methods, and disease models in sections that also describe recent research examples, such as recently developed cutting-edge in vitro and in vivo biomedical science methods to bridge the bench and bedside. This text is suitable for students, researchers and practitioners in biomedicine and basic medicine.Provides rigorous, cutting-edge research to educate readers of the relation of biomedical science and significant human diseasesDelivers educational and teaching materials to students and instructors in biomedicine, bioscience and human disease coursesIncludes glossary of terms and end of chapter exercises with answers, textboxes, tables and case studies throughout

The Kidney, Volume 7 in the Stem Cell Innovation in Health and Disease series explores the emerging potential of stem cell therapies in treating kidney diseases. With their natural regenerative and anti-inflammatory properties, stem cells offer a promising approach to restoring essential kidney functions and mitigating damage. This volume highlights how stem cell therapies may modulate immune responses, promote tissue repair, and replace damaged kidney cells, offering hope for chronic and acute renal conditions. Key developments include the injection of mesenchymal stem cells (MSCs) into damaged kidneys, where they can differentiate into kidney cell types and aid in healing. Urine-derived stem cells have also shown significant potential in improving kidney function in preclinical studies. Additionally, innovative techniques like incorporating MSCs into compact dialysis machines are being explored, enabling delivery of pro-repair factors directly to the kidneys during blood filtration. While there are currently no FDA-approved stem cell treatments for kidney diseases, ongoing clinical trials aim to evaluate their safety and efficacy. This volume compiles cutting-edge research, discussing various cell sources, underlying mechanisms, observed therapeutic outcomes, and the practical challenges of clinical translation. By presenting a clear picture of current advances and future directions, The Kidney serves as a vital resource for scientists, clinicians, and health innovators seeking to harness stem cell technology in nephrology.Provides cutting-edge research to understand stem cell functions used in disease and disorder treatments of the kidneyDevelops processes to bring stem cells from bench to bedsideIncludes up to date references on stem cell biology and function in common kidney diseases and disorders

This book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics.

This book reviews stem cell behavior in the lung as it relates to regenerative medicine and stem cell therapeutics. Topics ranging from basic developmental mechanisms of various types of lung stem cells through the identification and properties of stem cell behavior and their potential applications in lung repair and regeneration, are discussed by an expert in the field. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding of developmental lung stem cell biology and behavior and their potential applications. Lung Stem Cell Behavior is essential reading for researchers in stem cell biology and regenerative medicine, patient advocates, undergraduate students, graduate students, and clinicians interested in cellular therapy and tissue engineering therapies.

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders.Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.