Albert Y. Zomaya – författare

The mystique of biologically inspired (or bioinspired) paradigms is their ability to describe and solve complex relationships from intrinsically very simple initial conditions and with little or no knowledge of the search space. Edited by two prominent, well-respected researchers, the Handbook of Bioinspired Algorithms and Applications reveals the connections between bioinspired techniques and the development of solutions to problems that arise in diverse problem domains.A repository of the theory and fundamentals as well as a manual for practical implementation, this authoritative handbook provides broad coverage in a single source along with numerous references to the available literature for more in-depth information. The book's two sections serve to balance coverage of theory and practical applications. The first section explains the fundamentals of techniques, such as evolutionary algorithms, swarm intelligence, cellular automata, and others. Detailed examples and case studies in the second section illustrate how to apply the theory in actually developing solutions to a particular problem based on a bioinspired technique.Emphasizing the importance of understanding and harnessing the robust capabilities of bioinspired techniques for solving computationally intractable optimizations and decision-making applications, the Handbook of Bioinspired Algorithms and Applications is an absolute must-read for anyone who is serious about advancing the next generation of computing.

This book presents state-of-the-art solutions to the theoretical and practical challenges stemming from the leverage of big data and its computational intelligence in supporting smart network operation, management, and optimization. In particular, the technical focus covers the comprehensive understanding of network big data, efficient collection and management of network big data, distributed and scalable online analytics for network big data, and emerging applications of network big data for computational intelligence.

From the Foreword:"Big Data Management and Processing is [a] state-of-the-art book that deals with a wide range of topical themes in the field of Big Data. The book, which probes many issues related to this exciting and rapidly growing field, covers processing, management, analytics, and applications... [It] is a very valuable addition to the literature. It will serve as a source of up-to-date research in this continuously developing area. The book also provides an opportunity for researchers to explore the use of advanced computing technologies and their impact on enhancing our capabilities to conduct more sophisticated studies."---Sartaj Sahni, University of Florida, USA"Big Data Management and Processing covers the latest Big Data research results in processing, analytics, management and applications. Both fundamental insights and representative applications are provided. This book is a timely and valuable resource for students, researchers and seasoned practitioners in Big Data fields.--Hai Jin, Huazhong University of Science and Technology, ChinaBig Data Management and Processing explores a range of big data related issues and their impact on the design of new computing systems. The twenty-one chapters were carefully selected and feature contributions from several outstanding researchers. The book endeavors to strike a balance between theoretical and practical coverage of innovative problem solving techniques for a range of platforms. It serves as a repository of paradigms, technologies, and applications that target different facets of big data computing systems.The first part of the book explores energy and resource management issues, as well as legal compliance and quality management for Big Data. It covers In-Memory computing and In-Memory data grids, as well as co-scheduling for high performance computing applications. The second part of the book includes comprehensive coverage of Hadoop and Spark, along with security, privacy, and trust challenges and solutions.The latter part of the book covers mining and clustering in Big Data, and includes applications in genomics, hospital big data processing, and vehicular cloud computing. The book also analyzes funding for Big Data projects.

As computing devices proliferate, demand increases for an understanding of emerging computing paradigms and models based on natural phenomena. Neural networks, evolution-based models, quantum computing, and DNA-based computing and simulations are all a necessary part of modern computing analysis and systems development. Vast literature exists on these new paradigms and their implications for a wide array of applications. This comprehensive handbook, the first of its kind to address the connection between nature-inspired and traditional computational paradigms, is a repository of case studies dealing with different problems in computing and solutions to these problems based on nature-inspired paradigms. The "Handbook of Nature-Inspired and Innovative Computing: Integrating Classical Models with Emerging Technologies" is an essential compilation of models, methods, and algorithms for researchers, professionals, and advanced-level students working in all areas of computer science, IT, biocomputing, and network engineering.

A unique investigation of the state of the art in design, architectures, and implementations of advanced computational infrastructures and the applications they support Emerging large-scale adaptive scientific and engineering applications are requiring an increasing amount of computing and storage resources to provide new insights into complex systems. Due to their runtime adaptivity, these applications exhibit complicated behaviors that are highly dynamic, heterogeneous, and unpredictable—and therefore require full-fledged computational infrastructure support for problem solving, runtime management, and dynamic partitioning/balancing. This book presents a comprehensive study of the design, architecture, and implementation of advanced computational infrastructures as well as the adaptive applications developed and deployed using these infrastructures from different perspectives, including system architects, software engineers, computational scientists, and application scientists. Providing insights into recent research efforts and projects, the authors include descriptions and experiences pertaining to the realistic modeling of adaptive applications on parallel and distributed systems.The first part of the book focuses on high-performance adaptive scientific applications and includes chapters that describe high-impact, real-world application scenarios in order to motivate the need for advanced computational engines as well as to outline their requirements. The second part identifies popular and widely used adaptive computational infrastructures. The third part focuses on the more specific partitioning and runtime management schemes underlying these computational toolkits. Presents representative problem-solving environments and infrastructures, runtime management strategies, partitioning and decomposition methods, and adaptive and dynamic applications Provides a unique collection of selected solutions and infrastructures that have significant impact with sufficient introductory materials Includes descriptions and experiences pertaining to the realistic modeling of adaptive applications on parallel and distributed systems The cross-disciplinary approach of this reference delivers a comprehensive discussion of the requirements, design challenges, underlying design philosophies, architectures, and implementation/deployment details of advanced computational infrastructures. It makes it a valuable resource for advanced courses in computational science and software/systems engineering for senior undergraduate and graduate students, as well as for computational and computer scientists, software developers, and other industry professionals.

A visual, interdisciplinary approach to solving problems in numerical methods Computing for Numerical Methods Using Visual C++ fills the need for a complete, authoritative book on the visual solutions to problems in numerical methods using C++. In an age of boundless research, there is a need for a programming language that can successfully bridge the communication gap between a problem and its computing elements through the use of visual-ization for engineers and members of varying disciplines, such as biologists, medical doctors, mathematicians, economists, and politicians. This book takes an interdisciplinary approach to the subject and demonstrates how solving problems in numerical methods using C++ is dominant and practical for implementation due to its flexible language format, object-oriented methodology, and support for high numerical precisions.In an accessible, easy-to-follow style, the authors cover: Numerical modeling using C++ Fundamental mathematical tools MFC interfaces Curve visualization Systems of linear equations Nonlinear equations Interpolation and approximation Differentiation and integration Eigenvalues and Eigenvectors Ordinary differential equations Partial differential equations This reader-friendly book includes a companion Web site, giving readers free access to all of the codes discussed in the book as well as an equation parser called "MyParser" that can be used to develop various numerical applications on Windows. Computing for Numerical Methods Using Visual C++ serves as an excellent reference for students in upper undergraduate- and graduate-level courses in engineering, science, and mathematics. It is also an ideal resource for practitioners using Microsoft Visual C++.

Wiley Series in Bioinformatics: Computational Techniques and EngineeringYi Pan and Albert Y. Zomaya, Series Editors Wide coverage of traditional unsupervised and supervised methods and newer contemporary approaches that help researchers handle the rapid growth of classification methods in DNA microarray studies Proliferating classification methods in DNA microarray studies have resulted in a body of information scattered throughout literature, conference proceedings, and elsewhere. This book unites many of these classification methods in a single volume. In addition to traditional statistical methods, it covers newer machine-learning approaches such as fuzzy methods, artificial neural networks, evolutionary-based genetic algorithms, support vector machines, swarm intelligence involving particle swarm optimization, and more. Classification Analysis of DNA Microarrays provides highly detailed pseudo-code and rich, graphical programming features, plus ready-to-run source code. Along with primary methods that include traditional and contemporary classification, it offers supplementary tools and data preparation routines for standardization and fuzzification; dimensional reduction via crisp and fuzzy c-means, PCA, and non-linear manifold learning; and computational linguistics via text analytics and n-gram analysis, recursive feature extraction during ANN, kernel-based methods, ensemble classifier fusion. This powerful new resource: Provides information on the use of classification analysis for DNA microarrays used for large-scale high-throughput transcriptional studiesServes as a historical repository of general use supervised classification methods as well as newer contemporary methodsBrings the reader quickly up to speed on the various classification methods by implementing the programming pseudo-code and source code provided in the bookDescribes implementation methods that help shorten discovery timesClassification Analysis of DNA Microarrays is useful for professionals and graduate students in computer science, bioinformatics, biostatistics, systems biology, and many related fields.

The only single, up-to-date source for Grid issues in bioinformatics and biology Bioinformatics is fast emerging as an important discipline for academic research and industrial applications, creating a need for the use of Grid computing techniques for large-scale distributed applications. This book successfully presents Grid algorithms and their real-world applications, provides details on modern and ongoing research, and explores software frameworks that integrate bioinformatics and computational biology. Additional coverage includes: * Bio-ontology and data mining * Data visualization * DNA assembly, clustering, and mapping * Molecular evolution and phylogeny * Gene expression and micro-arrays * Molecular modeling and simulation * Sequence search and alignment * Protein structure prediction * Grid infrastructure, middleware, and tools for bio data Grid Computing for Bioinformatics and Computational Biology is an indispensable resource for professionals in several research and development communities including bioinformatics, computational biology, Grid computing, data mining, and more. It also serves as an ideal textbook for undergraduate- and graduate-level courses in bioinformatics and Grid computing.

A visual, interdisciplinary approach to solving problems in numerical methods

Computing for Numerical Methods Using Visual C++ fills the need for a complete, authoritative book on the visual solutions to problems in numerical methods using C++. In an age of boundless research, there is a need for a programming language that can successfully bridge the communication gap between a problem and its computing elements through the use of visual-ization for engineers and members of varying disciplines, such as biologists, medical doctors, mathematicians, economists, and politicians. This book takes an interdisciplinary approach to the subject and demonstrates how solving problems in numerical methods using C++ is dominant and practical for implementation due to its flexible language format, object-oriented methodology, and support for high numerical precisions.

In an accessible, easy-to-follow style, the authors cover:

Numerical modeling using C++

Fundamental mathematical tools

MFC interfaces

Curve visualization

Systems of linear equations

Nonlinear equations

Interpolation and approximation

Differentiation and integration

Eigenvalues and Eigenvectors

Ordinary differential equations

Partial differential equations

This reader-friendly book includes a companion Web site, giving readers free access to all of the codes discussed in the book as well as an equation parser called "MyParser" that can be used to develop various numerical applications on Windows. Computing for Numerical Methods Using Visual C++ serves as an excellent reference for students in upper undergraduate- and graduate-level courses in engineering, science, and mathematics. It is also an ideal resource for practitioners using Microsoft Visual C++.

Mathematics of Bioinformatics: Theory, Methods, and Applications provides a comprehensive format for connecting and integrating information derived from mathematical methods and applying it to the understanding of biological sequences, structures, and networks. Each chapter is divided into a number of sections based on the bioinformatics topics and related mathematical theory and methods. Each topic of the section is comprised of the following three parts: an introduction to the biological problems in bioinformatics; a presentation of relevant topics of mathematical theory and methods to the bioinformatics problems introduced in the first part; an integrative overview that draws the connections and interfaces between bioinformatics problems/issues and mathematical theory/methods/applications.

Cutting-edge solutions to current problems in orthopedics, supported by modeling and numerical analysisDespite the current successful methods and achievements of good joint implantations, it is essential to further optimize the shape of implants so they may better resist extreme long-term mechanical demands. This book provides the orthopedic, biomechanical, and mathematical basis for the simulation of surgical techniques in orthopedics. It focuses on the numerical modeling of total human joint replacements and simulation of their functions, along with the rigorous biomechanics of human joints and other skeletal parts. The book includes: An introduction to the anatomy and biomechanics of the human skeleton, biomaterials, and problems of alloarthroplastyThe definition of selected simulated orthopedic problemsConstructions of mathematical model problems of the biomechanics of the human skeleton and its partsReplacement parts of the human skeleton and corresponding mathematical model problemsDetailed mathematical analyses of mathematical models based on functional analysis and finite element methodsBiomechanical analyses of particular parts of the human skeleton, joints, and corresponding replacementsA discussion of the problems of data processing from nuclear magnetic resonance imaging and computer tomographyThis timely book offers a wealth of information on the current research in this field. The theories presented are applied to specific problems of orthopedics. Numerical results are presented and discussed from both biomechanical and orthopedic points of view and treatment methods are also briefly addressed. Emphasis is placed on the variational approach to the investigated model problems while preserving the orthopedic nature of the investigated problems. The book also presents a study of algorithmic procedures based on these simulation models.This is a highly useful tool for designers, researchers, and manufacturers of joint implants who require the results of suggested experiments to improve existing shapes or to design new shapes. It also benefits graduate students in orthopedics, biomechanics, and applied mathematics.

This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamentals right up to the latest, most advanced levels of study.

An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational intelligence and pattern analysis while deepening the reader's understanding of the ways in which these principles can be used for analyzing biological data in an efficient manner. This book synthesizes current research in the integration of computational intelligence and pattern analysis techniques, either individually or in a hybridized manner. The purpose is to analyze biological data and enable extraction of more meaningful information and insight from it. Biological data for analysis include sequence data, secondary and tertiary structure data, and microarray data. These data types are complex and advanced methods are required, including the use of domain-specific knowledge for reducing search space, dealing with uncertainty, partial truth and imprecision, efficient linear and/or sub-linear scalability, incremental approaches to knowledge discovery, and increased level and intelligence of interactivity with human experts and decision makers Chapters authored by leading researchers in CI in biology informatics.Covers highly relevant topics: rational drug design; analysis of microRNAs and their involvement in human diseases.Supplementary material included: program code and relevant data sets correspond to chapters.

This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamentals right up to the latest, most advanced levels of study.

The energy consumption issue in distributed computing systems raises various monetary, environmental and system performance concerns. Electricity consumption in the US doubled from 2000 to 2005.  From a financial and environmental standpoint, reducing the consumption of electricity is important, yet these reforms must not lead to performance degradation of the computing systems.  These contradicting constraints create a suite of complex problems that need to be resolved in order to lead to 'greener' distributed computing systems.  This book brings together a group of outstanding researchers that investigate the different facets of green and energy efficient distributed computing. Key features: One of the first books of its kindFeatures latest research findings on emerging topics by well-known scientistsValuable research for grad students, postdocs, and researchersResearch will greatly feed into other technologies and application domains

A highly accessible reference offering a broad range of topics and insights on large scale network-centric distributed systemsEvolving from the fields of high-performance computing and networking, large scale network-centric distributed systems continues to grow as one of the most important topics in computing and communication and many interdisciplinary areas. Dealing with both wired and wireless networks, this book focuses on the design and performance issues of such systems.Large Scale Network-Centric Distributed Systems provides in-depth coverage ranging from ground-level hardware issues (such as buffer organization, router delay, and flow control) to the high-level issues immediately concerning application or system users (including parallel programming, middleware, and OS support for such computing systems). Arranged in five parts, it explains and analyzes complex topics to an unprecedented degree: Part 1: Multicore and Many-Core (Mc) Systems-on-ChipPart 2: Pervasive/Ubiquitous Computing and Peer-to-Peer SystemsPart 3: Wireless/Mobile NetworksPart 4: Grid and Cloud ComputingPart 5: Other Topics Related to Network-Centric Computing and Its ApplicationsLarge Scale Network-Centric Distributed Systems is an incredibly useful resource for practitioners, postgraduate students, postdocs, and researchers.

A team of recognized experts leads the way to dependable computing systems With computers and networks pervading every aspect of daily life, there is an ever-growing demand for dependability. In this unique resource, researchers and organizations will find the tools needed to identify and engage state-of-the-art approaches used for the specification, design, and assessment of dependable computer systems. The first part of the book addresses models and paradigms of dependable computing, and the second part deals with enabling technologies and applications. Tough issues in creating dependable computing systems are also tackled, including:* Verification techniques* Model-based evaluation* Adjudication and data fusion* Robust communications primitives* Fault tolerance* Middleware* Grid security* Dependability in IBM mainframes* Embedded software* Real-time systems Each chapter of this contributed work has been authored by a recognized expert. This is an excellent textbook for graduate and advanced undergraduate students in electrical engineering, computer engineering, and computer science, as well as a must-have reference that will help engineers, programmers, and technologists develop systems that are secure and reliable.

Master the numerical simulation process required to design, test and support mobile and parallel computing systems. An accompanying ftp site contains all the Visual C++ based programs discussed in the text to help readers create their own programs. With its focus on problems and solutions, this is an excellent text for upper-level undergraduate and graduate students, and a must-have reference for researchers and professionals in the field of simulations. More information about Visual C++ based programs can be found at: ftp: //ftp.wiley.com/public/sci_tech_med/numerical_simulations/

Discover how to streamline complex bioinformatics applications with parallel computing This publication enables readers to handle more complex bioinformatics applications and larger and richer data sets. As the editor clearly shows, using powerful parallel computing tools can lead to significant breakthroughs in deciphering genomes, understanding genetic disease, designing customized drug therapies, and understanding evolution. A broad range of bioinformatics applications is covered with demonstrations on how each one can be parallelized to improve performance and gain faster rates of computation. Current parallel computing techniques and technologies are examined, including distributed computing and grid computing. Readers are provided with a mixture of algorithms, experiments, and simulations that provide not only qualitative but also quantitative insights into the dynamic field of bioinformatics. Parallel Computing for Bioinformatics and Computational Biology is a contributed work that serves as a repository of case studies, collectively demonstrating how parallel computing streamlines difficult problems in bioinformatics and produces better results. Each of the chapters is authored by an established expert in the field and carefully edited to ensure a consistent approach and high standard throughout the publication. The work is organized into five parts:* Algorithms and models* Sequence analysis and microarrays* Phylogenetics* Protein folding* Platforms and enabling technologies Researchers, educators, and students in the field of bioinformatics will discover how high-performance computing can enable them to handle more complex data sets, gain deeper insights, and make new discoveries.

Master the numerical simulation process required to design, test and support mobile and parallel computing systems. An accompanying ftp site contains all the Visual C++ based programs discussed in the text to help readers create their own programs. With its focus on problems and solutions, this is an excellent text for upper-level undergraduate and graduate students, and a must-have reference for researchers and professionals in the field of simulations. More information about Visual C++ based programs can be found at: ftp: //ftp.wiley.com/public/sci_tech_med/numerical_simulations/

Discover how to streamline complex bioinformatics applications with parallel computing This publication enables readers to handle more complex bioinformatics applications and larger and richer data sets. As the editor clearly shows, using powerful parallel computing tools can lead to significant breakthroughs in deciphering genomes, understanding genetic disease, designing customized drug therapies, and understanding evolution. A broad range of bioinformatics applications is covered with demonstrations on how each one can be parallelized to improve performance and gain faster rates of computation. Current parallel computing techniques and technologies are examined, including distributed computing and grid computing. Readers are provided with a mixture of algorithms, experiments, and simulations that provide not only qualitative but also quantitative insights into the dynamic field of bioinformatics. Parallel Computing for Bioinformatics and Computational Biology is a contributed work that serves as a repository of case studies, collectively demonstrating how parallel computing streamlines difficult problems in bioinformatics and produces better results. Each of the chapters is authored by an established expert in the field and carefully edited to ensure a consistent approach and high standard throughout the publication. The work is organized into five parts: * Algorithms and models * Sequence analysis and microarrays * Phylogenetics * Protein folding * Platforms and enabling technologies Researchers, educators, and students in the field of bioinformatics will discover how high-performance computing can enable them to handle more complex data sets, gain deeper insights, and make new discoveries.

The only single, up-to-date source for Grid issues in bioinformatics and biology Bioinformatics is fast emerging as an important discipline for academic research and industrial applications, creating a need for the use of Grid computing techniques for large-scale distributed applications. This book successfully presents Grid algorithms and their real-world applications, provides details on modern and ongoing research, and explores software frameworks that integrate bioinformatics and computational biology. Additional coverage includes:* Bio-ontology and data mining* Data visualization* DNA assembly, clustering, and mapping* Molecular evolution and phylogeny* Gene expression and micro-arrays* Molecular modeling and simulation* Sequence search and alignment* Protein structure prediction* Grid infrastructure, middleware, and tools for bio data Grid Computing for Bioinformatics and Computational Biology is an indispensable resource for professionals in several research and development communities including bioinformatics, computational biology, Grid computing, data mining, and more. It also serves as an ideal textbook for undergraduate- and graduate-level courses in bioinformatics and Grid computing.

This text advocates the viability of using fuzzy and annealing methods in solving scheduling problems for parallel computing systems. The book proposes new techniques for both static and dynamic scheduling, using emerging paradigms that are inspired by natural phenomena such as fuzzy logic, mean-field annealing, and simulated annealing. Systems that are designed using such techniques are often referred to in the literature as "intelligent" because of their capability to adapt to sudden changes in their environments. Moreover, most of these changes cannot be anticipated in advance or included in the original design of the system. The book provides results that prove such approaches can become viable alternatives to orthodox solutions to the scheduling problem, which are mostly based on heuristics. Although heuristics are robust and reliable when solving certain instances of the scheduling problem, they do not perform well when one needs to obtain solutions to general forms of the scheduling problem.On the other hand, techniques inspired by natural phenomena have been successfully applied for solving a wide range of combinatorial optimization problems, such as travelling salesman and graph partitioning. The success of these methods motivated their use in this book to solve scheduling problems that are known to be formidable combinatorial problems.

The mystique of biologically inspired (or bioinspired) paradigms is their ability to describe and solve complex relationships from intrinsically very simple initial conditions and with little or no knowledge of the search space. Edited by two prominent, well-respected researchers, the Handbook of Bioinspired Algorithms and Applications reveals the

This book represents the most comprehensive and up-to-date collection of information on the topic of computational molecular biology. Bringing the most recent research into the forefront of discussion, Algorithms in Computational Molecular Biology studies the most important and useful algorithms currently being used in the field, and provides related problems. It also succeeds where other titles have failed, in offering a wide range of information from the introductory fundamentals right up to the latest, most advanced levels of study.

The first comprehensive overview of preprocessing, mining, and postprocessing of biological dataMolecular biology is undergoing exponential growth in both the volume and complexity of biological data—and knowledge discovery offers the capacity to automate complex search and data analysis tasks. This book presents a vast overview of the most recent developments on techniques and approaches in the field of biological knowledge discovery and data mining (KDD)—providing in-depth fundamental and technical field information on the most important topics encountered.Written by top experts, Biological Knowledge Discovery Handbook: Preprocessing, Mining, and Postprocessing of Biological Data covers the three main phases of knowledge discovery (data preprocessing, data processing—also known as data mining—and data postprocessing) and analyzes both verification systems and discovery systems.BIOLOGICAL DATA PREPROCESSING Part A: Biological Data ManagementPart B: Biological Data ModelingPart C: Biological Feature ExtractionPart D Biological Feature SelectionBIOLOGICAL DATA MINING Part E: Regression Analysis of Biological DataPart F Biological Data ClusteringPart G: Biological Data ClassificationPart H: Association Rules Learning from Biological DataPart I: Text Mining and Application to Biological DataPart J: High-Performance Computing for Biological Data MiningCombining sound theory with practical applications in molecular biology, Biological Knowledge Discovery Handbook is ideal for courses in bioinformatics and biological KDD as well as for practitioners and professional researchers in computer science, life science, and mathematics.

Reviews the latest advances in the all-important field of scalable computingIn telecommunications and software engineering, scalability is the ability of a system, network, or process to either handle growing amounts of work in a graceful manner or be enlarged to accommodate that growth. It is a desirable property for many scientific, industrial, and business applications and an important feature for hardware.This immersive book summarizes the latest research achievements in the field of scalable computing and covers new topics that have emerged recently on computing and communications, such as unconventional computing, green and sustainable computing, cloud and volunteer computing, and more. Filled with contributions from world-renowned engineers, researchers, and IT professionals in diverse areas, Scalable Computing and Communications covers: Circuit and component designOperating systemsGreen computingNetwork-on-chip paradigmsComputational gridsHigh-performance computingSoftwareNetworking in scalable computing and mobile computingNext-generation networkingCloud computingPeer-to-peer systemsScalable Computing and Communications is well organized with basic concepts, software infrastructure and middleware, and applications and systems. Filled with numerous case studies, figures, and tables, it is a valuable book that offers great insight into future trends and emerging topics for professionals and students in the field.

Covers the fundamentals and techniques of multiple biological sequence alignment and analysis, and shows readers how to choose the appropriate sequence analysis tools for their tasksThis book describes the traditional and modern approaches in biological sequence alignment and homology search.  This book contains 11 chapters, with Chapter 1 providing basic information on biological sequences. Next, Chapter 2 contains fundamentals in pair-wise sequence alignment, while Chapters 3 and 4 examine popular existing quantitative models and practical clustering techniques that have been used in multiple sequence alignment. Chapter 5 describes, characterizes and relates many multiple sequence alignment models. Chapter 6 describes how traditionally phylogenetic trees have been constructed, and available sequence knowledge bases can be used to improve the accuracy of reconstructing phylogeny trees. Chapter 7 covers the latest methods developed to improve the run-time efficiency of multiple sequence alignment.  Next, Chapter 8 covers several popular existing multiple sequence alignment server and services, and Chapter 9 examines several multiple sequence alignment techniques that have been developed to handle short sequences (reads) produced by the Next Generation Sequencing technique (NSG). Chapter 10 describes a Bioinformatics application using multiple sequence alignment of short reads or whole genomes as input. Lastly, Chapter 11 provides a review of RNA and protein secondary structure prediction using the evolution information inferred from multiple sequence alignments.• Covers the full spectrum of the field, from alignment algorithms to scoring methods, practical techniques, and alignment tools and their evaluations• Describes theories and developments of scoring functions and scoring matrices•Examines phylogeny estimation and large-scale homology searchMultiple Biological Sequence Alignment: Scoring Functions, Algorithms and Applications is a reference for researchers, engineers, graduate and post-graduate students in bioinformatics, and system biology and molecular biologists.Ken Nguyen, PhD, is an associate professor at Clayton State University, GA, USA. He received his PhD, MSc and BSc degrees in computer science all from Georgia State University. His research interests are in databases, parallel and distribute computing and bioinformatics. He was a Molecular Basis of Disease fellow at Georgia State and is the recipient of the highest graduate honor at Georgia State, the William M. Suttles Graduate Fellowship.Xuan Guo, PhD, is a postdoctoral associate at Oak Ridge National Lab, USA. He received his PhD degree in computer science from Georgia State University in 2015. His research interests are in bioinformatics, machine leaning, and cloud computing. He is an editorial assistant of International Journal of Bioinformatics Research and Applications.Yi Pan, PhD, is a Regents' Professor of Computer Science and an Interim Associate Dean and Chair of Biology at Georgia State University. He received his BE and ME in computer engineering from Tsinghua University in China and his PhD in computer science from the University of Pittsburgh. Dr. Pan's research interests include parallel and distributed computing, optical networks, wireless networks and bioinformatics. He has published more than 180 journal papers with about 60 papers published in various IEEE/ACM journals. He is co-editor along with Albert Y. Zomaya of the Wiley Series in Bioinformatics.