Alberto D'Onofrio – författare

This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account.

With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.

​​Since the parameters in dynamical systems of biological interest are inherently positive and bounded, bounded noises are a natural way to model the realistic stochastic fluctuations of a biological system that are caused by its interaction with the external world. Bounded Noises in Physics, Biology, and Engineering is the first contributed volume devoted to the modeling of bounded noises in theoretical and applied statistical mechanics, quantitative biology, and mathematical physics. It gives an overview of the current state-of-the-art and is intended to stimulate further research.

The volume is organized in four parts. The first part presents the main kinds of bounded noises and their applications in theoretical physics. The theory of bounded stochastic processes is intimately linked to its applications to mathematical and statistical physics, and it would be difficult and unnatural to separate the theory from its physical applications. The second is devoted to framing bounded noises in the theory of random dynamical systems and random bifurcations, while the third is devoted to applications of bounded stochastic processes in biology, one of the major areas of potential applications of this subject. The final part concerns the application of bounded stochastic processes in mechanical and structural engineering, the area where the renewed interest for non-Gaussian bounded noises started. Pure mathematicians working on stochastic calculus will find here a rich source of problems that are challenging from the point of view of contemporary nonlinear analysis.

Bounded Noises in Physics, Biology, and Engineering is intended for scientists working on stochasticprocesses with an interest in both fundamental issues and applications. It will appeal to a broad range of applied mathematicians, mathematical biologists, physicists, engineers, and researchers in other fields interested in complexity theory. It is accessible to anyone with a working knowledge of stochastic modeling, from advanced undergraduates to senior researchers.

With chapters on free boundaries, constitutive equations, stochastic dynamics, nonlinear diffusion–consumption, structured populations, and applications of optimal control theory, this volume presents the most significant recent results in the field of mathematical oncology. It highlights the work of world-class research teams, and explores how different researchers approach the same problem in various ways.

Tumors are complex entities that present numerous challenges to the mathematical modeler. First and foremost, they grow. Thus their spatial mean field description involves a free boundary problem. Second, their interiors should be modeled as nontrivial porous media using constitutive equations. Third, at the end of anti-cancer therapy, a small number of malignant cells remain, making the post-treatment dynamics inherently stochastic. Fourth, the growth parameters of macroscopic tumors are non-constant, as are the parameters of anti-tumor therapies. Changes in these parameters may induce phenomena that are mathematically equivalent to phase transitions. Fifth, tumor vascular growth is random and self-similar. Finally, the drugs used in chemotherapy diffuse and are taken up by the cells in nonlinear ways.

Mathematical Oncology 2013 will appeal to graduate students and researchers in biomathematics, computational and theoretical biology, biophysics, and bioengineering.

The book "Problems in Mathematical Biophysics - a volume in memory of Alberto Gandolfi" aims at reviewing the current state of the art of the mathematical approach to various areas of theoretical biophysics. Leading authors in the field have been invited to contribute, having a strong appreciation of Alberto Gandolfi as a scientist and as a man and sharing his same passion for biology and medicine, as well as his style of investigation. Encompassing both theoretical and practical aspects of Mathematical Biophysics, the topics covered in this book span a spectrum of different problems, in biology, and medicine, including population dynamics, tumor growth and control, immunology, epidemiology, ecology, and others. As a result, the book offers a comprehensive and current overview of compelling subjects and challenges within the realm of mathematical biophysics. In their contributions, the authors have effectively conveyed not only their research findings but also their peculiar perspective and approach to problem-solving, dealing with oncology, epidemiology, neuro-sciences, and biochemistry. The chapters pertain to a wide array of mathematical areas such as continuous Markov chains, partial differential equations, kinetic theory, applied statistical mechanics, noise-induced transitions, and many others.

The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.