Arpana Parihar - Böcker

Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology.

Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems.

Covers design and development of advanced platforms for rapid diagnosis of cancerous biomarkers Takes a multidisciplinary approach to sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical systems, and device packaging for point-of-care applications Offers an insight into how to develop cost-effective diagnostics for early detection of cancer

Advanced Biosensors for Virus Detection: Smart Diagnostics to Combat Against the SARS-CoV2 Pandemic covers the development of biosensor-based approaches for the diagnosis and prognosis of viral infections, specifically coronaviruses. The book discusses wide-ranging topics of available biosensor-based technologies and their application for early viral detection. Sections cover the emergence of SARS-CoV, MERS-CoV and SARS-CoV2, the global health response, the impact on affected populations, state-of-the art biomarkers, and risk factors. Specific focus is given to COVID-19, with coverage of genomic profiling, strain variation and the pathogenesis of SARS-CoV2.

In addition, current therapeutics, nano-abled advancements and challenges in the detection of SARS-CoV2 and COVID-19 management are discussed, along with the role of nanomaterials in the development of biosensors and how biosensors can be scaled up for clinical applications and commercialization.

Deals with biosensors-based approaches that could be exploited to design and develop high throughput, rapid and cost-effective diagnostics technologies for the early detection of viral infections Illustrates the development of multiplexed, miniaturized analytical systems for point-of-care applications Provides information about fabrication protocols for various biosensor based diagnostic approaches that could be directly implemented to develop a novel biosensor Includes the past, present and future status of biosensors, along with information about biosensors currently under clinical trials

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection.

This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches.

Covers computational based approaches for designing and repurposing drugs Discusses immunoinformatic and reverse vaccinomic approaches for effective vaccine design Categorizes information about artificial intelligence-based drug screening and diagnostic tools

Smart Diagnostics for Neurodegenerative Disorders: Neuro-sensors explores all available biosensor-based approaches and technologies as well as their use in the diagnosis, prognosis and therapeutic management of a variety of neurological disorders such as Alzheimer's, Parkinson's and epileptic disorders. The book also discusses contemporary and revolutionary biosensor platforms that are being used to produce a quantitative quick lab-on-a-chip point-of-care (POC) assay for several types of predictive and diagnostic biomarkers linked with neurodegenerative disorders. It offers a combinatorial strategy for learning recent advances and designing new biosensor-based technologies in the fields of medical science, engineering and biomedical technology.

Early detection of neurological conditions has the potential to treat the disease and extend the life expectancy of patients. Recent improvements in biosensor-based approaches that target specific cell surface biomarkers can be used for early detection of neurodegenerative disease.

Provides an in-depth understanding of biomarkers associated with neurodegenerative disease to build and create a variety of biosensors Presents biosensor-based strategies to create and construct enhanced platforms for quick diagnosis of biomarkers linked to a variety of neurological illnesses Discusses the current challenges and future trends in developing diagnostic devices for early detection of neurodegenerative disorders, presenting new avenues for more sensitive and selective point-of-care devices

Wearable Smart Sensing Devices for Sustainable Healthcare: Techniques, Fabrication, Data Collection and Analysis presents a complete overview of the techniques for developing integrated wearable sensors, the systems that power them, and the fabrication issues involved in making them. The book bridges the gap between theory and practice, offering scientific knowledge and practical insights. Written by renowned researchers and industry experts, this book provides valuable understanding and insights into the design, data processing, analysis, and fabrication of wearable sensors that is ideal for academic engineering and scientific researchers, industry engineers, and scientists interested in developing wearable sensor devices.Presents a practical approach to designing and fabricating wearable sensors, covering lightweight hardware, energy harvesting, signal processing, and wireless communicationsExplores practical challenges related to smart fabrics, biomonitoring, and health informatics, addressing real-world problems faced by professionals in these areasGives a deep understanding of designing wearable devices from an end user perspectiveDiscusses ethical and safety considerationsPresents future trends for wearable sensors in the field of disease diagnostics and personalized healthcare management

3D Bioprinting and Bio-Regenerative Medicine for Personalized Oncology: Innovations for Personalized Oncology presents a comprehensive exploration of the transformative role of 3-D bioprinting and bio-generative engineering in modern medicine, with a specific focus on precision oncology. By examining innovative applications of these technologies, the book aims to bridge the gap between emerging scientific advancements and their practical implications in clinical settings. It delves into how patient-specific models of human tissues and organs can revolutionize drug testing, disease diagnostics, and personalized treatment plans, ultimately enhancing the quality of cancer care.Addressing critical challenges in oncology, this book highlights how 3-D bioprinting and bio-generative engineering can improve the accuracy of drug efficacy evaluations, reduce reliance on animal testing, and tackle the pressing issue of organ shortages for transplantation. Furthermore, it emphasizes the ethical considerations and regulatory challenges associated with integrating these technologies into everyday oncology practice, ensuring a balanced perspective on their adoption.Provides a comprehensive exploration on how 3D bioprinting and bio-regenerative engineering can create patient-specific models of human tissues and organsAddresses the ethical considerations and regulatory challenges associated with integrating advanced bioprinting technologies into clinical practiceFosters innovation and collaboration across disciplines, aiming to enhance our understanding of bio-generative engineering's role in precision oncology

The design and fabrication of aptamer-based biosensors for point-of-care testing of disease diagnostic and prognostic is an upthrust and interdisciplinary area of research. This book covers the design and development of novel cost-effective aptamer-based biosensors for disease diagnostic and prognostic including an understanding of health care management in terms of timely updates of disease situations in a particular geographical area. It also discusses the scaling up and market trend of aptamer-based devices for extension of research from lab to market, and end users.Features:Explains the design and fabrication of aptasensors-based diagnostic devicesIncludes novel approaches and comprehensive technology overview for diagnosis management towards early-stage detection of various biomarkers associated with several health conditionsDemonstrates possible benefits of combined diagnostics and therapeutic possibilities using aptamer-based point-of-care technologies devicesDiscusses emerging implications and recent advances of biosensing platforms for designing and developing aptamer-based point-of-care testing (POCT) devicesExplores aptamer-based approach to develop advanced platforms for medical applications and open arena for state-of-the-art future researchThis book is aimed at researchers and graduate students in biomedical engineering, diagnostics, nanobiotechnology, and materials science.

The design and fabrication of aptamer-based biosensors for point-of-care testing of disease diagnostic and prognostic is an upthrust and interdisciplinary area of research. This book covers the design and development of novel cost-effective aptamer-based biosensors for disease diagnostic and prognostic including an understanding of health care management in terms of timely updates of disease situations in a particular geographical area. It also discusses the scaling up and market trend of aptamer-based devices for extension of research from lab to market, and end users.Features:Explains the design and fabrication of aptasensors-based diagnostic devicesIncludes novel approaches and comprehensive technology overview for diagnosis management towards early-stage detection of various biomarkers associated with several health conditionsDemonstrates possible benefits of combined diagnostics and therapeutic possibilities using aptamer-based point-of-care technologies devicesDiscusses emerging implications and recent advances of biosensing platforms for designing and developing aptamer-based point-of-care testing (POCT) devicesExplores aptamer-based approach to develop advanced platforms for medical applications and open arena for state-of-the-art future researchThis book is aimed at researchers and graduate students in biomedical engineering, diagnostics, nanobiotechnology, and materials science.

This book explores the design, synthesis, and characterization of natural and synthetic polymeric biomaterials for diverse biomedical applications, including drug delivery, tissue engineering, and antimicrobial coatings. It highlights advances in polymer chemistry, offering insights into the modification of polymers’ properties to meet biomedical challenges. The book provides detailed strategies for material design and characterization, addressing practical issues faced by researchers. It also covers crucial aspects such as materials-tissue interaction, sterilization prior to in vivo use, and the characterization of biomaterials for development. Serving as a comprehensive guide for students, researchers, and professionals in the biomedical field, this book aims to bridge the gap between laboratory research and clinical applications.

Advanced materials are engineered to exhibit novel properties that confer superior performance in comparison with conventional materials. The performance of advanced materials is associated with toughness, hardness, and durability that can be used for high technological applications such as semiconductors, biomaterials, smart materials, or nanomaterials.Advanced Materials: Production, Characterization and Multidisciplinary Applications is focused on novel approaches for production of graphene and other 2D materials along with characterization techniques, discussing a wide range of applications in multidisciplinary areas of science and engineering. It provides a guiding light in the production, synthesis, and characterization of advanced materials by implementing appropriate techniques. The book has a multidisciplinary approach covering applications in electronics (sensors), engineering, biotechnology, medical (e.g., cancer treatment, drug delivery, cellular imaging), and biomedical (smart implants, drug delivery, and DIY health testing kits) fields. The authors cover the primary information of advanced and other 2D materials related to their production or synthesis via various methods, ranging from conventional to non‑conventional – such as lithography, photolithography (computer chips), electron beam lithography, etching, atomic layer deposition, chemical vapor deposition, hydrothermal process, and electrospinning, along with some comparative investigations. It also covers a comparison study over the current and future perspectives of advanced and other 2D materials.This book is aimed at researchers, academics, and professionals who are interested in understanding the novel approaches for synthesis of advanced materials.

The global miniature devices market is poised to surpass a valuation of $12–$15 billion USD by the year 2030. Lab-on-a-chip (LOC) devices are a vital component of this market.Comprising a network of microchannels, electrical circuits, sensors, and electrodes, LOC is a miniaturized integrated device platform used to streamline day-to-day laboratory functions, run cost-effective clinical analyses and curb the need for centralized instrumentation facilities in remote areas. Compact design, portability, ease of operation, low sample volume, short reaction time, and parallel investigation stand as the pivotal factors driving the widespread acceptance of LOC within the biomedical community.In this book, the Editors meticulously explore LOC through three key ‘Ts’: Theories (microfluidics, microarrays, instrumentation, software);Technologies (additive manufacturing, artificial intelligence, computational thinking, smart consumables, scale-up tactics, and biofouling); and Trends (biomedical analysis, point-of-care diagnostics, personalized healthcare, bioactive synthesis, disease diagnosis, and space applications) This comprehensive text not only provides readers with a thorough understanding of the current advancements in the LOC domain but also offers valuable insights to support the utilization of miniaturized devices for enhanced healthcare practices. Aimed at career researchers looking for instruction in the topic and newcomers to the area, the book is also useful for undergraduate and postgraduate students embarking on new studies or for those interested in reading about the LOC platform.