Nidhi Puranik – författare

This book aims to discuss the various drug delivery approaches of neuroprotective medicines via nanoparticles, such as enzymes, monoclonal antibodies, neurotrophic factors, pharmaceutical drugs, and nucleic acid-based medication, to manage Alzheimer's disease.Nanomedicine in the Treatment and Management of Alzheimer's Disease investigates drug administration approaches, either separately or in combination, to improve neuroprotection in Alzheimer's disease. The book examines various novel therapeutic applications of nanomaterials in drug delivery for the central nervous system in Alzheimer's disease treatment. The book explores the role of nanoparticles in crossing the blood–brain barrier and blood-CSF barrier in the treatment and management of Alzheimer's disease. The authors also explain the nanoparticle-based delivery of therapeutic molecules including phytochemicals, peptides, siRNA, enzymes, and monoclonal antibodies in the treatment of Alzheimer's disease. Finally, the book also discusses the various challenges and future perspectives of nanomedicine in the management of Alzheimer’s disease.The book will help in bridging the gap of knowledge in neurosciences, neurotherapeutics, nanotechnology, and nanomedicine domains. The book chapter may be useful to educators, researchers, legislators, and medical professionals including pharmacologists, biochemists, corporate pharma R&D researchers, neurologists, and scientists involved in neurodegenerative diseases and nanomedicine.

This book explores the role of proteostasis in neurodegenerative disorders, focusing on protein homeostasis in long-lived, nondividing cells like neurons. It examines how disruptions in proteostasis, influenced by factors such as oxidative stress, aging, and environmental stress, contribute to diseases like Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. The book begins with an overview of the epidemiology and management of neurodegenerative diseases. Subsequent chapters delve into the mechanisms governing proteostasis, highlighting the ubiquitin-proteasome system, molecular chaperones, and co-chaperones in protein folding and degradation. It further explores how impairments in these pathways contribute to neuroinflammation and disease progression. By providing insights into these cellular processes, the book aims to enhance understanding and support the development of potential therapeutic strategies.