Proteostasis

Investigating Molecular Dynamics in Neurodegenerative Disorders

Inbunden, Engelska, 2025

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Beskrivning

This book explores the role of proteostasis in neurodegenerative disorders, focusing on protein homeostasis in long-lived, nondividing cells like neurons. It examines how disruptions in proteostasis, influenced by factors such as oxidative stress, aging, and environmental stress, contribute to diseases like Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. The book begins with an overview of the epidemiology and management of neurodegenerative diseases. Subsequent chapters delve into the mechanisms governing proteostasis, highlighting the ubiquitin-proteasome system, molecular chaperones, and co-chaperones in protein folding and degradation. It further explores how impairments in these pathways contribute to neuroinflammation and disease progression. By providing insights into these cellular processes, the book aims to enhance understanding and support the development of potential therapeutic strategies.

Produktinformation

Utgivningsdatum:2025-07-13
Mått:155 x 235 x 28 mm
Vikt:913 g
Format:Inbunden
Språk:Engelska
Antal sidor:429
Förlag:Springer Nature Switzerland AG
ISBN:9789819662012

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Mer om författaren

Dr. Nidhi Puranik is a Research Assistant Professor in the Department of Life Science at Yeungnam University in Gyeongsan, Korea of Republic. She did her Ph.D. at DRDO-Defence Research & Development Establishment (Research Center) and her degree was awarded from Bharathair University, Coimbatore, Tamilnadu, India. She has more than 10 years of research and teaching experience in the field of disease therapeutics and diagnostics. Her current research is focused on the screening and development of plant-based drugs for various diseases. She has been awarded the prestigious GATE, CSIR-NET, ICAR-NET, DRDO Junior research fellowship, MPCST Young Scientist award, MPCST Young Scientist training fellowship (National), and Young Investigator award (International). She has worked in various prestigious institutes of India- ICMR-NIREH, Bhopal, ICAR-IISR, Indore, Jiwaji University, Gwalior, DRDE, Gwalior, and Barkatullah University, Bhopal. She has authored over 40 highly cited research articles, secured an Indian patent, and edited books for Springer Nature, IOP Publishing, and CRC Press.

Innehållsförteckning

1. Neurodegenerative disorder: An overview.- 2. Alzheimer's: Epidemiology, pathophysiology, diagnosis and treatments.- 3. Parkinson’s Disease: Epidemiology, Pathophysiology, Diagnosis, and Treatment.- 4. A Proteasome System and Impairment in Ubiquitin-Proteasome System in Neurodegeneration and Neuroprotection.- 5. Protein misfolding and cell death in neurodegenerative diseases: consequences and strategies.- 6. Proteostasis disturbances and inflammation in neurodegenerative diseases.- 7. Proteostasis: Investigating Molecular Dynamics in Neurodegenerative Disorders.- 8. Biomarkers for Proteostasis Disruption: An Overview.- 9. Insights into Proteostasis System in Ageing and Neurodegenerative Disorders.- 10. The role of chaperones and cochaperones in synaptic proteostasis and neurodegenerative disease.- 11. Proteasomal Degradation and Autophagy in Neurodegenerative Diseases.- 12. The Insight into the Role of Protein Misfolding and Tau Oligomers in Alzheimer's Disease.- 13. Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease.- 14. A comprehensive review of the ubiquitin-proteasome system in synapse remodeling and neurodegenerative diseases.- 15. Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases.- 16. Ameliorative Effects of Heat Shock Proteins in Therapeutic Implications of Neurodegenerative Diseases.- 17. Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.- 18. Future Perspectives and Challenges in the Field of Proteostasis and Neurodegenerative Disorders.