Atanas Pavlov – författare

The genus Salvia represents nearly 1,000 species that are widely distributed around the world. It is the largest in the Lamiaceae family. Traditionally, infusions of Salvia species have been widely used to treat oral inflammation, throat and headaches, and digestive disturbances in various folklore- and ethno-medicine practices worldwide. The antispasmodic, antiseptic and hypoglycemic effects of their extracts have been recognized by the ancient healers a long time ago before the development of modern medicine. With the advances in phytochemistry and pharmacology, terpenes, polyphenols and volatile compounds have been recognized as the source of bioactivity in Salvia extracts. Nowadays, because of their valuable pharmaceutical and nutraceutical properties, many Salvia species have been widely used as ingredients in food, pharmacy and cosmetic industries. The economic importance of Salvia plants continues to increase, following closely the growing interest to the concept for modern healthy lifestyle, based on prevention by consuming quality foods and nutraceutical supplements of natural origin.However, the growing demand has led to overexploitation of natural habitats and in the last few years many wild growing Salvia species have shrunk or fallen under threat. Obviously, to deal with that problem and to prevent ecological crisis, there is an urgent need for alternative, renewable sources of Salvia biomass. Plant biotechnology can provide a wide range of tools for development of economically feasible continuous production of standardized valuable phytochemicals. Plant in vitro culture technology is a powerful method for continuous production of plant secondary metabolites under controlled conditions, recently adapted to various Salvia species. Salvia in vitro systems are harmless to natural plant populations and can be grown independently of environmental factors, geographical latitude, climatic change, and seasonal variations. Several bioactive metabolites from rare and endangered Salvia plants can be produced by employing different plant in vitro systems. However, the researches on development of large scale biotechnology, based on Salvia in vitro systems, are still in early stages and many points still have to be addressed before the commercialization to take place.In this book we intend to summarize the recent achievements in research with Salvia in vitro systems as biological matrixes for the production of pharmaceutically important secondary metabolites. Further we invited leading experts to present their recent studies on phytochemistry, ethnobotanical and ethnophamacological aspects of genus Salvia. Safety and legal issues related to implementation of Salvia plants and in vitro cultures extracts in foods, cosmetics and pharmaceutical products will be discussed as well.

This handbook presents how plant in vitro technologies can overcome current limitations in the production of important plant-derived substances. It explains the advantages of plant in vitro technologies, notably the independence from climatic and soil conditions and the ability to synthesize diverse bioactive substances under controlled conditions. Apart from making diverse metabolites, which can be used e.g. as pharmaceuticals, agrochemicals, flavors, colors, biopesticides or food additives, more easily and more efficiently available, the methods described in this handbook also offer the advantage that rare and threatened plants, which provide access to interesting and desired substances, can be better protected, when the substances are harvested from suitable plant in vitro systems. In times of increasing demand for natural plant-derived products, the described methodologies will be key to ensuring efficient and sustainable access to plant-derived products. They will also help and support in the research and investigation of plant secondary metabolites.Despite these advantages, still only few substances are being produced at industrial scale by in vitro plant cell cultivation systems to date. This handbook therefore advertises the recent achievements and research in the field, focused on solving limitations in yield and bioprocessing conditions. Leading experts summarize the methodology, which can help overcome drawbacks like low yields of target products or problems associated with the cultivation in bioreactors. Readers will find comprehensive information on fundamentals for using different types of plants in vitro as matrix for sustainable production of valuable secondary metabolites. The handbook summarizes the core information on phytochemistry, bioreactor technology and monitoring of plant cells and tissues in bioprocesses. It also discusses selected applications and safety assessment of food and cosmetic ingredients from plantcell and tissue.

This handbook presents how plant in vitro technologies can overcome current limitations in the production of important plant-derived substances. It explains the advantages of plant in vitro technologies, notably the independence from climatic and soil conditions and the ability to synthesize diverse bioactive substances under controlled conditions. Apart from making diverse metabolites, which can be used e.g. as pharmaceuticals, agrochemicals, flavors, colors, biopesticides or food additives, more easily and more efficiently available, the methods described in this handbook also offer the advantage that rare and threatened plants, which provide access to interesting and desired substances, can be better protected, when the substances are harvested from suitable plant in vitro systems. In times of increasing demand for natural plant-derived products, the described methodologies will be key to ensuring efficient and sustainable access to plant-derived products. They will also help and support in the research and investigation of plant secondary metabolites.Despite these advantages, still only few substances are being produced at industrial scale by in vitro plant cell cultivation systems to date. This handbook therefore advertises the recent achievements and research in the field, focused on solving limitations in yield and bioprocessing conditions. Leading experts summarize the methodology, which can help overcome drawbacks like low yields of target products or problems associated with the cultivation in bioreactors. Readers will find comprehensive information on fundamentals for using different types of plants in vitro as matrix for sustainable production of valuable secondary metabolites. The handbook summarizes the core information on phytochemistry, bioreactor technology and monitoring of plant cells and tissues in bioprocesses. It also discusses selected applications and safety assessment of food and cosmetic ingredients from plantcell and tissue.

The genus Salvia represents nearly 1,000 species that are widely distributed around the world. It is the largest in the Lamiaceae family. Traditionally, infusions of Salvia species have been widely used to treat oral inflammation, throat and headaches, and digestive disturbances in various folklore- and ethno-medicine practices worldwide. The antispasmodic, antiseptic and hypoglycemic effects of their extracts have been recognized by the ancient healers a long time ago before the development of modern medicine. With the advances in phytochemistry and pharmacology, terpenes, polyphenols and volatile compounds have been recognized as the source of bioactivity in Salvia extracts. Nowadays, because of their valuable pharmaceutical and nutraceutical properties, many Salvia species have been widely used as ingredients in food, pharmacy and cosmetic industries. The economic importance of Salvia plants continues to increase, following closely the growing interest to the concept for modern healthy lifestyle, based on prevention by consuming quality foods and nutraceutical supplements of natural origin.However, the growing demand has led to overexploitation of natural habitats and in the last few years many wild growing Salvia species have shrunk or fallen under threat. Obviously, to deal with that problem and to prevent ecological crisis, there is an urgent need for alternative, renewable sources of Salvia biomass. Plant biotechnology can provide a wide range of tools for development of economically feasible continuous production of standardized valuable phytochemicals. Plant in vitro culture technology is a powerful method for continuous production of plant secondary metabolites under controlled conditions, recently adapted to various Salvia species. Salvia in vitro systems are harmless to natural plant populations and can be grown independently of environmental factors, geographical latitude, climatic change, and seasonal variations. Several bioactive metabolites from rare and endangered Salvia plants can be produced by employing different plant in vitro systems. However, the researches on development of large scale biotechnology, based on Salvia in vitro systems, are still in early stages and many points still have to be addressed before the commercialization to take place.In this book we intend to summarize the recent achievements in research with Salvia in vitro systems as biological matrixes for the production of pharmaceutically important secondary metabolites. Further we invited leading experts to present their recent studies on phytochemistry, ethnobotanical and ethnophamacological aspects of genus Salvia. Safety and legal issues related to implementation of Salvia plants and in vitro cultures extracts in foods, cosmetics and pharmaceutical products will be discussed as well.

The genus Salvia represents nearly 1,000 species that are widely distributed around the world. It is the largest in the Lamiaceae family. Traditionally, infusions of Salvia species have been widely used to treat oral inflammation, throat and headaches, and digestive disturbances in various folklore- and ethno-medicine practices worldwide. The antispasmodic, antiseptic and hypoglycemic effects of their extracts have been recognized by the ancient healers a long time ago before the development of modern medicine. With the advances in phytochemistry and pharmacology, terpenes, polyphenols and volatile compounds have been recognized as the source of bioactivity in Salvia extracts. Nowadays, because of their valuable pharmaceutical and nutraceutical properties, many Salvia species have been widely used as ingredients in food, pharmacy and cosmetic industries. The economic importance of Salvia plants continues to increase, following closely the growing interest to the concept for modern healthy lifestyle, based on prevention by consuming quality foods and nutraceutical supplements of natural origin.

However, the growing demand has led to overexploitation of natural habitats and in the last few years many wild growing Salvia species have shrunk or fallen under threat. Obviously, to deal with that problem and to prevent ecological crisis, there is an urgent need for alternative, renewable sources of Salvia biomass. Plant biotechnology can provide a wide range of tools for development of economically feasible continuous production of standardized valuable phytochemicals. Plant in vitro culture technology is a powerful method for continuous production of plant secondary metabolites under controlled conditions, recently adapted to various Salvia species. Salvia in vitro systems are harmless to natural plant populations and can be grown independently of environmental factors, geographical latitude, climatic change, and seasonal variations. Several bioactive metabolites from rare and endangered Salvia plants can be produced by employing different plant in vitro systems. However, the researches on development of large scale biotechnology, based on Salvia in vitro systems, are still in early stages and many points still have to be addressed before the commercialization to take place.

In this book we intend to summarize the recent achievements in research with Salvia in vitro systems as biological matrixes for the production of pharmaceutically important secondary metabolites. Further we invited leading experts to present their recent studies on phytochemistry, ethnobotanical and ethnophamacological aspects of genus Salvia. Safety and legal issues related to implementation of Salvia plants and in vitro cultures extracts in foods, cosmetics and pharmaceutical products will be discussed as well.