Avia Rosenhouse-Dantsker – författare

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12 produkter

Cholesterol Modulation of Protein Function
Sterol Specificity and Indirect Mechanisms
AvAvia Rosenhouse-Dantsker,Anna N. Bukiya
Inbunden, Engelska, 2019
1 798 kr
Skickas inom 10-15 vardagar
In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Cholesterol Modulation of Protein Function
Sterol Specificity and Indirect Mechanisms
AvAnna N. Bukiya,Avia Rosenhouse-Dantsker
E-bok
Engelska, 2019
2 267 kr
Läs direkt efter köp
In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed.
This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function.
The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Del 1135 - Advances in Experimental Medicine and Biology
Direct Mechanisms in Cholesterol Modulation of Protein Function
AvAvia Rosenhouse-Dantsker,Anna N. Bukiya
Inbunden, Engelska, 2019
1 094 kr
Skickas inom 10-15 vardagar
In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Direct Mechanisms in Cholesterol Modulation of Protein Function
AvAnna N. Bukiya,Avia Rosenhouse-Dantsker
E-bok
Engelska, 2019
1 459 kr
Läs direkt efter köp
In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis.
Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.

The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Del 1135 - Advances in Experimental Medicine and Biology
Direct Mechanisms in Cholesterol Modulation of Protein Function
AvAvia Rosenhouse-Dantsker,Anna N. Bukiya
Häftad, Engelska, 2020
1 094 kr
Skickas inom 10-15 vardagar
In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Cholesterol and PI(4,5)P2 in Vital Biological Functions
From Coexistence to Crosstalk
AvAvia Rosenhouse- Dantsker
Inbunden, Engelska, 2023
2 398 kr
Skickas inom 10-15 vardagar
Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each other’s levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes. This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI(4,5)P2 functions extend from parallel existence to crosstalk. It includes four sections. The first section introduces the reader to cholesterol and PI(4,5)P2. The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer proteins. The fourth section highlights other cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement. Collectively, the book portrays the emerging relationship between cholesterol and PI(4,5)P2 in a broad array of biological systems and processes. The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems, as well as graduate students, postdoctoral trainees, basic and clinical researchers, and pharmaceutical scientists. Specifically, the content will be relevant to researchers in the fields of biochemistry, molecular biophysics, pharmacology, neurobiology, cardiovascular biology, among others.Provides a comprehensive overview of the current knowledge of the interplay between cholesterol and PI(4,5) P2Provides an overview of the emerging relationship between cholesterol and PI(4,5)P2 in biological systems and processesDiscusses cellular processes and molecular mechanisms where lipid functions extend from parallel existence to crosstalk
Cholesterol and PI(4,5)P2 in Vital Biological Functions
From Coexistence to Crosstalk
AvAvia Rosenhouse- Dantsker
E-bok
Engelska, 2023
3 148 kr
Läs direkt efter köp
Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each other’s levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes.
This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI(4,5)P2 functions extend from parallel existence to crosstalk. It includes four sections. The first section introduces the reader to cholesterol and PI(4,5)P2. The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer proteins. The fourth section highlights other cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement. Collectively, the book portrays the emerging relationship between cholesterol and PI(4,5)P2 in a broad array of biological systems and processes.
The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems, as well as graduate students, postdoctoral trainees, basic and clinical researchers, and pharmaceutical scientists. Specifically, the content will be relevant to researchers in the fields of biochemistry, molecular biophysics, pharmacology, neurobiology, cardiovascular biology, among others.
Provides a comprehensive overview of the current knowledge of the interplay between cholesterol and PI(4,5) P2
Provides an overview of the emerging relationship between cholesterol and PI(4,5)P2 in biological systems and processes
Discusses cellular processes and molecular mechanisms where lipid functions extend from parallel existence to crosstalk
Cholesterol and PI(4,5)P2 in Vital Biological Functions : From Coexistence to Crosstalk
AvAvia Rosenhouse- Dantsker
Engelska, 2023
648 kr
Skickas inom 5-8 vardagar
Unlocking Protein Structure-Function Relationships
Computational and Experimental Approaches and Applications
AvAvia Rosenhouse-Dantsker
Inbunden, Engelska, 2026
2 177 kr
Skickas inom 10-15 vardagar
Unraveling the complex mechanisms governing the relationship between protein structure and function requires a multifaceted approach. In particular, the integration of experimental and computational approaches is exceptionally powerful in this context. However, while experimental techniques, such as X-ray crystallography and nuclear magnetic resonance (NMR), have been used for protein structure determination for over half a century, only in the last decade have computational tools gained sufficient power to assume a prominent role in the study of protein structure and function alongside experimental techniques. This volume offers a comprehensive overview of contemporary computational and experimental methods employed in protein structure-function studies, organized into two sections. The computational methods section delves into protein structure prediction, advanced simulation techniques, artificial intelligence and machine learning, ligand binding site identification, and protein-protein interaction prediction. The experimental methods section focuses on state-of-the-art structural methods, fluorescence microscopy, imaging techniques, and model membrane systems. This book is an invaluable resource for a wide audience of research scientists with an interest in the molecular and cellular facets of biological processes, especially those who seek to investigate the intricate world of proteins and their functions through cutting-edge methodologies.
Unlocking Protein Structure-Function Relationships
Computational and Experimental Approaches and Applications
AvAvia Rosenhouse-Dantsker
E-bok
Engelska, 2026
2 833 kr
Läs direkt efter köp
Unraveling the complex mechanisms governing the relationship between protein structure and function requires a multifaceted approach. In particular, the integration of experimental and computational approaches is exceptionally powerful in this context. However, while experimental techniques, such as X-ray crystallography and nuclear magnetic resonance (NMR), have been used for protein structure determination for over half a century, only in the last decade have computational tools gained sufficient power to assume a prominent role in the study of protein structure and function alongside experimental techniques. This volume offers a comprehensive overview of contemporary computational and experimental methods employed in protein structure-function studies, organized into two sections. The computational methods section delves into protein structure prediction, advanced simulation techniques, artificial intelligence and machine learning, ligand binding site identification, and protein-protein interaction prediction. The experimental methods section focuses on state-of-the-art structural methods, fluorescence microscopy, imaging techniques, and model membrane systems. This book is an invaluable resource for a wide audience of research scientists with an interest in the molecular and cellular facets of biological processes, especially those who seek to investigate the intricate world of proteins and their functions through cutting-edge methodologies.
Decoding Ion Channels Structure and Function
Computational and Experimental Studies
AvAvia Rosenhouse-Dantsker
Inbunden, Engelska, 2026
2 242 kr
Skickas inom 10-15 vardagar
Unraveling the intricate mechanisms underlying ion channel structure and function requires a multifaceted approach. In this context, the synergistic integration of experimental and computational approaches is exceptionally powerful. However, it is only in the past decade that computational tools have garnered sufficient power to play a prominent role alongside experimental techniques. This volume highlights cutting-edge approaches for studying ion channel structure and function, providing methodological advances with broad applications and offering targeted insights into various channels, organized into two sections. The first section presents fundamental computational and experimental approaches central to ion channel research, including theoretical frameworks for delineating the forces that govern ion selectivity, molecular dynamics simulations for elucidating ion channel gating, advanced structural and fluorescence-based techniques, and mutagenesis-centered integrative methods. The second section explores the structure and function of a wide array of channel types, including the voltage-gated hERG potassium channel, two-pore domain potassium channels, the ryanodine receptor intracellular calcium channel, transient receptor potential vanilloid (TRPV) channels, pentameric ligand-gated ion channels, and aquaporin ion channels.Together, these chapters demonstrate how contemporary experimental and computational methods advance our understanding of ion channel structure and function. Showcasing these advances, this book is an invaluable resource for researchers and professionals in the ion channel field and the pharmaceutical industry.
Decoding Ion Channels Structure and Function
Computational and Experimental Studies
AvAvia Rosenhouse-Dantsker
E-bok
Engelska, 2026
2 917 kr
Läs direkt efter köp
Unraveling the intricate mechanisms underlying ion channel structure and function requires a multifaceted approach. In this context, the synergistic integration of experimental and computational approaches is exceptionally powerful. However, it is only in the past decade that computational tools have garnered sufficient power to play a prominent role alongside experimental techniques. This volume highlights cutting-edge approaches for studying ion channel structure and function, providing methodological advances with broad applications and offering targeted insights into various channels, organized into two sections. The first section presents fundamental computational and experimental approaches central to ion channel research, including theoretical frameworks for delineating the forces that govern ion selectivity, molecular dynamics simulations for elucidating ion channel gating, advanced structural and fluorescence-based techniques, and mutagenesis-centered integrative methods. The second section explores the structure and function of a wide array of channel types, including the voltage-gated hERG potassium channel, two-pore domain potassium channels, the ryanodine receptor intracellular calcium channel, transient receptor potential vanilloid (TRPV) channels, pentameric ligand-gated ion channels, and aquaporin ion channels.Together, these chapters demonstrate how contemporary experimental and computational methods advance our understanding of ion channel structure and function. Showcasing these advances, this book is an invaluable resource for researchers and professionals in the ion channel field and the pharmaceutical industry.

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Avia Rosenhouse-Dantsker – författare

Cholesterol Modulation of Protein Function

Cholesterol Modulation of Protein Function

Direct Mechanisms in Cholesterol Modulation of Protein Function

Direct Mechanisms in Cholesterol Modulation of Protein Function

Direct Mechanisms in Cholesterol Modulation of Protein Function

Cholesterol and PI(4,5)P2 in Vital Biological Functions

Cholesterol and PI(4,5)P2 in Vital Biological Functions

Cholesterol and PI(4,5)P2 in Vital Biological Functions : From Coexistence to Crosstalk

Unlocking Protein Structure-Function Relationships

Unlocking Protein Structure-Function Relationships

Decoding Ion Channels Structure and Function

Decoding Ion Channels Structure and Function

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