Ayman O. Soubani – författare

This book serves as a guide to the pulmonary and critical care complications  of hematopoietic stem cell transplantation (HSCT). HSCT is an important therapeutic modality for a variety of malignant and non-malignant conditions. The outcomes of these patients have been improving and the number of HSCT cases is increasing around the world. These patients, however, continue to have post-transplant complications related to conditioning regimens and graft vs. host disease. Pulmonary complications following HSCT remain a major cause of morbidity and mortality in this patient population.The book begins with an overview of HSCT and graft vs. host disease. Chapters then cover particular complications, including immunological changes in lungs, diffuse alveolar hemorrhage, bronchiolitis obliterans and pulmonary fibrosis. Other complications, including neurologic, renal, gastrointestinal, and cardiac, are covered. Chapters are comprehensive and consistent with each defining the scope of the complication, epidemiology, risk factors, diagnostic approach, management, outcome and predictors of outcome, and future directions. The book provides insight as well on matters that arise during the care of HSCT patients such as provider burnout, nursing care, intensive care unit organization, nutritional support, and pulmonary and physical rehabilitation.This is an ideal guide for pulmonologists, critical care physicians, transplant specialists, oncologists, and relevant trainees caring for patients who have undergone HSCT.

This book serves as a guide to the pulmonary and critical care complications  of hematopoietic stem cell transplantation (HSCT). HSCT is an important therapeutic modality for a variety of malignant and non-malignant conditions. The outcomes of these patients have been improving and the number of HSCT cases is increasing around the world. These patients, however, continue to have post-transplant complications related to conditioning regimens and graft vs. host disease. Pulmonary complications following HSCT remain a major cause of morbidity and mortality in this patient population.The book begins with an overview of HSCT and graft vs. host disease. Chapters then cover particular complications, including immunological changes in lungs, diffuse alveolar hemorrhage, bronchiolitis obliterans and pulmonary fibrosis. Other complications, including neurologic, renal, gastrointestinal, and cardiac, are covered. Chapters are comprehensive and consistent with each defining the scope of the complication, epidemiology, risk factors, diagnostic approach, management, outcome and predictors of outcome, and future directions. The book provides insight as well on matters that arise during the care of HSCT patients such as provider burnout, nursing care, intensive care unit organization, nutritional support, and pulmonary and physical rehabilitation.This is an ideal guide for pulmonologists, critical care physicians, transplant specialists, oncologists, and relevant trainees caring for patients who have undergone HSCT.

This is a comprehensive, in-depth presentation of pulmonary aspergillosis that takes into consideration recent advances in diagnosis and management. Aspergillus is an opportunistic fungus that is ubiquitous in nature and is unique in the spectrum of illness that it may cause. These may range from fulminant invasive pulmonary aspergillosis (IPA) to chronic pulmonary infection to a hypersensitivity reaction in the form of allergic bronchopulmonary aspergillosis (ABPA).IPA was primarily associated with severe immunocompromised diseases such as leukemia or bone marrow transplantation and diagnosis and management proved difficult. However, there have been significant advances in the diagnosis with the use of non-invasive biomarkers and in the management with more tolerable and effective antifungal agents. The COVID-19 pandemic has also played a role in making pulmonary aspergillosis much more prevalent with expanding risk factors across populations. This book aims to fill the gap and prepare clinicians to deal with this previously rare disease.The text is divided into six sections. Expert authors start with the basics of microbiology, immunology, and pathology and then move on to clinical and diagnostic considerations. The text is then divided between IPA, chronic pulmonary aspergillosis, and ABPA and the specific considerations of each are detailed. Finally, chapters cover specific and unique areas that complement the full understanding of this topic.           The wide spectrum of conditions associated with pulmonary aspergillosis, the expanding risk factors and the improvement in the diagnosis and management of these conditions, make this entity relevant to all pulmonologists, intensivists, and infectious disease specialists rather than only those practicing in highly specialized centers.

This book aims to equip the reader to make optimal decisions on the use of mechanical ventilatory support in critically ill cancer patients with acute respiratory failure (ARF) and to implement the different strategies effectively.